SLC29A4

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Solute carrier family 29 (equilibrative nucleoside transporter), member 4
Identifiers
Symbols SLC29A4 ; ENT4; PMAT
External IDs OMIM609149 MGI2385330 HomoloGene71345 GeneCards: SLC29A4 Gene
Orthologs
Species Human Mouse
Entrez 222962 243328
Ensembl ENSG00000164638 ENSMUSG00000050822
UniProt Q7RTT9 Q8R139
RefSeq (mRNA) NM_001040661 NM_146257
RefSeq (protein) NP_001035751 NP_666369
Location (UCSC) Chr 7:
5.31 – 5.35 Mb
Chr 5:
142.7 – 142.72 Mb
PubMed search [1] [2]

Equilibrative nucleoside transporter 4 is a protein that in humans is encoded by the SLC29A4 gene.[1][2]

This gene is a member of the SLC29 family and encodes a plasma membrane protein with 11 transmembrane helices. This protein catalyzes the reuptake of monoamines into presynaptic neurons, thus determining the intensity and duration of monoamine neural signaling. It has been shown to transport several compounds, including serotonin, dopamine, and the neurotoxin 1-methyl-4-phenylpyridinium. Alternate transcriptional splice variants which encode the same protein have been characterized.[2]

See also[edit]

References[edit]

  1. ^ Baldwin SA, Beal PR, Yao SY, King AE, Cass CE, Young JD (Feb 2004). "The equilibrative nucleoside transporter family, SLC29". Pflugers Arch 447 (5): 735–43. doi:10.1007/s00424-003-1103-2. PMID 12838422. 
  2. ^ a b "Entrez Gene: SLC29A4 solute carrier family 29 (nucleoside transporters), member 4". 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.