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Solute carrier family 2 (facilitated glucose transporter), member 9
External IDs OMIM606142 MGI2152844 HomoloGene69290 GeneCards: SLC2A9 Gene
RNA expression pattern
PBB GE SLC2A9 219991 at tn.png
More reference expression data
Species Human Mouse
Entrez 56606 117591
Ensembl ENSG00000109667 ENSMUSG00000005107
UniProt Q9NRM0 B9EHN5
RefSeq (mRNA) NM_001001290 NM_001012363
RefSeq (protein) NP_001001290 NP_001012363
Location (UCSC) Chr 4:
9.77 – 10.06 Mb
Chr 5:
38.35 – 38.5 Mb
PubMed search [1] [2]

Solute carrier family 2, facilitated glucose transporter member 9 is a protein that in humans is encoded by the SLC2A9 gene.[1][2][3]

This gene encodes a member of the SLC2A facilitative glucose transporter family. Members of this family play a significant role in maintaining glucose homeostasis. The encoded protein may play a role in the development and survival of chondrocytes in cartilage matrices. Two transcript variants encoding distinct isoforms have been identified for this gene.[3]

SLC2A9 has also recently been found to transport uric acid, and genetic variants of the transporter have been linked to increased risk of development of both hyperuricemia and gout.[4][5]

See also[edit]


  1. ^ Phay JE, Hussain HB, Moley JF (Aug 2000). "Cloning and expression analysis of a novel member of the facilitative glucose transporter family, SLC2A9 (GLUT9)". Genomics 66 (2): 217–20. doi:10.1006/geno.2000.6195. PMID 10860667. 
  2. ^ Manolescu AR, Augustin R, Moley K, Cheeseman C (Aug 2007). "A highly conserved hydrophobic motif in the exofacial vestibule of fructose transporting SLC2A proteins acts as a critical determinant of their substrate selectivity". Mol Membr Biol 24 (5-6): 455–63. doi:10.1080/09687680701298143. PMID 17710649. 
  3. ^ a b "Entrez Gene: SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9". 
  4. ^ Vitart V, Rudan I, Hayward C, et al. (2008). "SLC2A9 is a newly identified urate transporter influencing serum urate concentration, urate excretion and gout". Nature Genetics 40 (4): 437. doi:10.1038/ng.106. PMID 18327257. 
  5. ^ Döring A, Gieger C, Mehta D, et al. (2008). "SLC2A9 influences uric acid concentrations with pronounced sex-specific effects". Nature Genetics 40 (4): 430. doi:10.1038/ng.107. PMID 18327256. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.