SLC30A3

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Solute carrier family 30 (zinc transporter), member 3
Identifiers
Symbols SLC30A3 ; ZNT3
External IDs OMIM602878 HomoloGene74470 GeneCards: SLC30A3 Gene
Orthologs
Species Human Mouse
Entrez 7781 22784
Ensembl ENSG00000115194 ENSMUSG00000029151
UniProt Q99726 P97441
RefSeq (mRNA) NM_003459 NM_011773
RefSeq (protein) NP_003450 NP_035903
Location (UCSC) Chr 2:
27.48 – 27.5 Mb
Chr 5:
31.09 – 31.09 Mb
PubMed search [1] [2]

Zinc transporter 3 also known as solute carrier family 30 member 3 is a protein in humans that is encoded by the SLC30A3 gene.[1]

The SLC30A3 gene codes for the ZnT-3 SLC30A family membrane transport protein. ZnT-3 is required for the accumulation of zinc ions inside synaptic vesicles.[2] In mice, ZnT-3 is required for some forms of memory that depend on the hippocampus and the amygdala.[3] Zinc transport by ZnT-3 modulates memory formation by acting through the extracellular signal-regulated kinases signaling pathway.[4] Angiotensin II-induced senescence of vascular smooth muscle cells requires down-regulation of ZnT-3 and ZnT-10.[5]

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