SLC30A8

Solute carrier family 30 (zinc transporter), member 8
Identifiers
Symbols	SLC30A8; ZNT8; ZnT-8
External IDs	OMIM: 611145 MGI: 2442682 HomoloGene: 13795 GeneCards: SLC30A8 Gene
Gene Ontology Molecular function • zinc ion transmembrane transporter activity • zinc ion binding • cation transmembrane transporter activity • protein homodimerization activity Cellular component • Golgi apparatus • plasma membrane • integral to membrane • cytoplasmic membrane-bounded vesicle • secretory granule • transport vesicle membrane • secretory granule membrane Biological process • zinc ion transport • cellular zinc ion homeostasis • response to glucose stimulus • insulin secretion • positive regulation of insulin secretion • sequestering of zinc ion • response to interferon-gamma • glucose homeostasis • transmembrane transport • regulation of vesicle-mediated transport • regulation of sequestering of zinc ion • response to interleukin-1 • zinc ion transmembrane transport Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	169026	239436
Ensembl	ENSG00000164756	ENSMUSG00000022315
UniProt	Q8IWU4	Q8BGG0
RefSeq (mRNA)	NM_001172811.1	NM_172816.3
RefSeq (protein)	NP_001166282.1	NP_766404.1
Location (UCSC)	Chr 8: 117.96 – 118.19 Mb	Chr 15: 52.13 – 52.17 Mb
PubMed search	[1]	[2]

Solute carrier family 30 (zinc transporter), member 8, also known as SLC30A8, is a human gene that codes for a zinc transporter related to insulin secretion in humans. Certain alleles of this gene may increase the risk for developing type 2 diabetes.

See also

• Solute carrier family

Further reading

• Chimienti F, Favier A, Seve M (2006). "ZnT-8, a pancreatic beta-cell-specific zinc transporter.". Biometals 18 (4): 313–7. doi:10.1007/s10534-005-3687-9. PMID 16158222. 
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=310948. 
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=311072. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Seve M, Chimienti F, Devergnas S, Favier A (2004). "In silico identification and expression of SLC30 family genes: an expressed sequence tag data mining strategy for the characterization of zinc transporters' tissue expression.". BMC Genomics 5: 32. doi:10.1186/1471-2164-5-32. PMC 428573. PMID 15154973. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=428573. 
• Chimienti F, Devergnas S, Favier A, Seve M (2004). "Identification and cloning of a beta-cell-specific zinc transporter, ZnT-8, localized into insulin secretory granules.". Diabetes 53 (9): 2330–7. doi:10.2337/diabetes.53.9.2330. PMID 15331542. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528930. 
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1347501. 
• Sladek R, Rocheleau G, Rung J, et al. (2007). "A genome-wide association study identifies novel risk loci for type 2 diabetes.". Nature 445 (7130): 881–5. doi:10.1038/nature05616. PMID 17293876. 
• Wenzlau JM, Juhl K, Yu L, et al. (2007). "The cation efflux transporter ZnT8 (Slc30A8) is a major autoantigen in human type 1 diabetes.". Proc. Natl. Acad. Sci. U.S.A. 104 (43): 17040–5. doi:10.1073/pnas.0705894104. PMC 2040407. PMID 17942684. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2040407. 

External links

• Type 2 diabetes genes mapped out, BBC News article