SLC31A1

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Solute carrier family 31 (copper transporters), member 1
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols SLC31A1 ; COPT1; CTR1
External IDs OMIM603085 MGI1333843 HomoloGene1399 GeneCards: SLC31A1 Gene
RNA expression pattern
PBB GE SLC31A1 203971 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 1317 20529
Ensembl ENSG00000136868 ENSMUSG00000066150
UniProt O15431 Q8K211
RefSeq (mRNA) NM_001859 NM_175090
RefSeq (protein) NP_001850 NP_780299
Location (UCSC) Chr 9:
115.98 – 116.03 Mb
Chr 4:
62.36 – 62.39 Mb
PubMed search [1] [2]

High affinity copper uptake protein 1 is a protein that in humans is encoded by the SLC31A1 gene.[1][2]

Copper is an element essential for life, but excessive copper can be toxic or even lethal to the cell. Therefore, cells have developed sophisticated ways to maintain a critical copper balance, with the intake, export, and intracellular compartmentalization or buffering of copper strictly regulated. The 2 related genes ATP7A (MIM 300011) and ATP7B (MIM 606882), responsible for the human diseases Menkes syndrome (MIM 309400) and Wilson disease (MIM 277900), respectively, are involved in copper export. In S. cerevisiae, the copper uptake genes CTR1, CTR2, and CTR3 have been identified, and in human the CTR1 and CTR2 (MIM 603088) genes have been identified.[supplied by OMIM][2]

See also[edit]

References[edit]

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.