SLC46A1

Solute carrier family 46 (folate transporter), member 1
Identifiers
Symbols	SLC46A1; FLJ39875; HCP1; MGC9564; PCFT
External IDs	OMIM: 611672 MGI: 1098733 HomoloGene: 41693 GeneCards: SLC46A1 Gene
Gene Ontology Molecular function • transporter activity • folic acid binding • folic acid transporter activity • folic acid transporter activity • heme transporter activity Cellular component • cytoplasm • plasma membrane • plasma membrane • integral to membrane • apical plasma membrane Biological process • vitamin metabolic process • water-soluble vitamin metabolic process • cellular iron ion homeostasis • folic acid transport • folic acid transport • heme transport • folic acid metabolic process • transmembrane transport Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	113235	52466
Ensembl	ENSG00000076351	ENSMUSG00000020829
UniProt	Q96NT5	Q6PEM8
RefSeq (mRNA)	NM_001242366.1	NM_026740.2
RefSeq (protein)	NP_001229295.1	NP_081016.2
Location (UCSC)	Chr 17: 26.72 – 26.73 Mb	Chr 11: 78.28 – 78.29 Mb
PubMed search	[1]	[2]

Solute carrier family 46 (folate transporter), member 1 (SLC46A1) also known as proton-coupled folate transporter (PCFT), is a protein which in humans is encoded by the SLC46A1 gene.

Function

SLC46A1 is responsible for the intestinal uptake of folate.

Further reading

• Subramanian VS, Marchant JS, Said HM (2008). "Apical membrane targeting and trafficking of the human proton-coupled transporter in polarized epithelia.". Am. J. Physiol., Cell Physiol. 294 (1): C233–40. doi:10.1152/ajpcell.00468.2007. PMID 18003745. 
• Nakai Y, Inoue K, Abe N, et al. (2007). "Functional characterization of human proton-coupled folate transporter/heme carrier protein 1 heterologously expressed in mammalian cells as a folate transporter.". J. Pharmacol. Exp. Ther. 322 (2): 469–76. doi:10.1124/jpet.107.122606. PMID 17475902. 
• Zhao R, Min SH, Qiu A, et al. (2007). "The spectrum of mutations in the PCFT gene, coding for an intestinal folate transporter, that are the basis for hereditary folate malabsorption.". Blood 110 (4): 1147–52. doi:10.1182/blood-2007-02-077099. PMC 1939898. PMID 17446347. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1939898. 
• Sharma S, Dimasi D, Bröer S, et al. (2007). "Heme carrier protein 1 (HCP1) expression and functional analysis in the retina and retinal pigment epithelium.". Exp. Cell Res. 313 (6): 1251–9. doi:10.1016/j.yexcr.2007.01.019. PMID 17335806. 
• Latunde-Dada GO, Takeuchi K, Simpson RJ, McKie AT (2007). "Haem carrier protein 1 (HCP1): Expression and functional studies in cultured cells.". FEBS Lett. 580 (30): 6865–70. doi:10.1016/j.febslet.2006.11.048. PMID 17156779. 
• Qiu A, Jansen M, Sakaris A, et al. (2007). "Identification of an intestinal folate transporter and the molecular basis for hereditary folate malabsorption.". Cell 127 (5): 917–28. doi:10.1016/j.cell.2006.09.041. PMID 17129779. 
• Shayeghi M, Latunde-Dada GO, Oakhill JS, et al. (2005). "Identification of an intestinal heme transporter.". Cell 122 (5): 789–801. doi:10.1016/j.cell.2005.06.025. PMID 16143108. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 

External links

• GeneReview/NIH/UW entry on Hereditary Folate Malabsorption