SLC47A1

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Solute carrier family 47, member 1
Identifiers
Symbols SLC47A1 ; MATE1
External IDs OMIM609832 MGI1914723 HomoloGene34364 ChEMBL: 1743126 GeneCards: SLC47A1 Gene
RNA expression pattern
PBB GE FLJ10847 219525 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 55244 67473
Ensembl ENSG00000142494 ENSMUSG00000010122
UniProt Q96FL8 Q8K0H1
RefSeq (mRNA) NM_018242 NM_026183
RefSeq (protein) NP_060712 NP_080459
Location (UCSC) Chr 17:
19.4 – 19.48 Mb
Chr 11:
61.34 – 61.38 Mb
PubMed search [1] [2]

Multidrug and toxin extrusion protein 1 (MATE1), also known as solute carrier family 47, member 1, is a protein that in humans is encoded by the SLC47A1 gene.[1][2] SLC47A1 belongs to the MATE (multidrug and toxic compound extrusion) family of transporters that are found in bacteria, archaea and eukaryotes.[3][4]

Gene[edit]

The SLC47A1 gene is located within the Smith-Magenis syndrome region on chromosome 17.[1]

Function[edit]

SLC47A1 is a member of the MATE family of transporters that excrete endogenous and exogenous toxic electrolytes through urine and bile.[2]

Discovery[edit]

The multidrug efflux transporter NorM from V. parahaemolyticus which mediates resistance to multiple antimicrobial agents (norfloxacin, kanamycin, ethidium bromide etc.) and its homologue from E. coli were identified in 1998, which is the first of Solute carrier family 47 member.[3] NorM seems to function as drug/sodium antiporter which is the first example of Na+-coupled multidrug efflux transporter.[5] NorM is a prototype of a new transporter family and Brown et al.. named it the multidrug and toxic compound extrusion family.[4] The X-ray structure of the transporter NorM was determined to 3.65 Å, revealing an outward-facing conformation with two portals open to the outer leaflet of the membrane and a unique topology of the predicted 12 transmembrane helices distinct from any other known multidrug resistance transporter.[6]

See also[edit]

  • MATE (Multi antimicrobial extrusion protein or multidrug and toxic compound extrusion protein)

References[edit]

  1. ^ a b "Entrez Gene: FLJ10847 hypothetical protein FLJ10847". 
  2. ^ a b Otsuka M, Matsumoto T, Morimoto R, Arioka S, Omote H, Moriyama Y (December 2005). "A human transporter protein that mediates the final excretion step for toxic organic cations". Proc. Natl. Acad. Sci. U.S.A. 102 (50): 17923–8. doi:10.1073/pnas.0506483102. PMC 1312386. PMID 16330770. 
  3. ^ a b Morita Y, Kodama K, Shiota S, Mine T, Kataoka A, Mizushima T, Tsuchiya T (July 1998). "NorM, a putative multidrug efflux protein, of Vibrio parahaemolyticus and its homolog in Escherichia coli". Antimicrob. Agents Chemother. 42 (7): 1778–82. PMC 105682. PMID 9661020. 
  4. ^ a b Brown MH, Paulsen IT, Skurray RA (January 1999). "The multidrug efflux protein NorM is a prototype of a new family of transporters". Mol. Microbiol. 31 (1): 394–5. doi:10.1046/j.1365-2958.1999.01162.x. PMID 9987140. 
  5. ^ Morita Y, Kataoka A, Shiota S, Mizushima T, Tsuchiya T (December 2000). "NorM of vibrio parahaemolyticus is an Na(+)-driven multidrug efflux pump". J. Bacteriol. 182 (23): 6694–7. doi:10.1128/JB.182.23.6694-6697.2000. PMC 111412. PMID 11073914. 
  6. ^ He X, Szewczyk P, Karykin A, Hong WX, Zhang Q, Chang G (2010). "Structure of a cation-bound multidrug and toxic compound extrusion transporter". Nature 467 (7318): 991–4. doi:10.1038/nature09408. PMC 3152480. PMID 20861838. 

Further reading[edit]