SLC4A5

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Solute carrier family 4, sodium bicarbonate cotransporter, member 5
Identifiers
Symbols SLC4A5 ; NBC4
External IDs OMIM606757 MGI2443220 HomoloGene31125 GeneCards: SLC4A5 Gene
RNA expression pattern
PBB GE SLC4A5 221723 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 57835 232156
Ensembl ENSG00000188687 ENSMUSG00000068323
UniProt Q9BY07 D3YVG0
RefSeq (mRNA) NM_021196 NM_001166067
RefSeq (protein) NP_067019 NP_001159539
Location (UCSC) Chr 2:
74.44 – 74.57 Mb
Chr 6:
83.22 – 83.3 Mb
PubMed search [1] [2]

Electrogenic sodium bicarbonate cotransporter 4 is a protein that in humans is encoded by the SLC4A5 gene.[1][2][3]

Function[edit]

This gene encodes a member of the sodium bicarbonate cotransporter (NBC) family, part of the bicarbonate transporter superfamily. Sodium bicarbonate cotransporters are involved in intracellular pH regulation and electroneural or electrogenic sodium bicarbonate transport. This protein is thought to be an integral membrane protein. Multiple transcript variants encoding different isoforms have been found for this gene, but the biological validity of some variants has not been determined.[3]

Clinical significance[edit]

This human gene has been identified as a hypertension susceptibility gene based on the association of single nucleotide polymorphisms with blood pressure (BP) levels and hypertension status.[4]

See also[edit]

References[edit]

  1. ^ Pushkin A, Abuladze N, Newman D, Lee I, Xu G, Kurtz I (Nov 2000). "Cloning, characterization and chromosomal assignment of NBC4, a new member of the sodium bicarbonate cotransporter family". Biochim Biophys Acta 1493 (1–2): 215–8. doi:10.1016/S0167-4781(00)00149-4. PMID 10978526. 
  2. ^ Pushkin A, Abuladze N, Newman D, Lee I, Xu G, Kurtz I (Mar 2001). "Two C-terminal variants of NBC4, a new member of the sodium bicarbonate cotransporter family: cloning, characterization, and localization". IUBMB Life 50 (1): 13–9. doi:10.1080/15216540050176539. PMID 11087115. 
  3. ^ a b "Entrez Gene: SLC4A5 solute carrier family 4, sodium bicarbonate cotransporter, member 5". 
  4. ^ Gröger N, Vitzthum H, Fröhlich H, Krüger M, Ehmke H, Braun T, Boettger T (March 2012). "Targeted mutation of SLC4A5 induces arterial hypertension and renal metabolic acidosis". Hum. Mol. Genet. 21 (5): 1025–36. doi:10.1093/hmg/ddr533. PMID 22082831. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.