SLC4A8

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Solute carrier family 4, sodium bicarbonate cotransporter, member 8
Identifiers
Symbols SLC4A8 ; NBC3; NDCBE
External IDs OMIM605024 MGI1928745 HomoloGene68419 IUPHAR: 912 GeneCards: SLC4A8 Gene
RNA expression pattern
PBB GE SLC4A8 207056 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 9498 59033
Ensembl ENSG00000050438 ENSMUSG00000023032
UniProt Q2Y0W8 Q8JZR6
RefSeq (mRNA) NM_001039960 NM_001033218
RefSeq (protein) NP_001035049 NP_067505
Location (UCSC) Chr 12:
51.79 – 51.9 Mb
Chr 15:
100.76 – 100.82 Mb
PubMed search [1] [2]

Electroneutral sodium bicarbonate exchanger 1 is a protein that in humans is encoded by the SLC4A8 gene.[1][2]

See also[edit]

Interactions[edit]

SLC4A8 has been shown to interact with Sodium-hydrogen antiporter 3 regulator 1[3][4] and Cystic fibrosis transmembrane conductance regulator.[4]

References[edit]

  1. ^ Grichtchenko II, Choi I, Zhong X, Bray-Ward P, Russell JM, Boron WF (May 2001). "Cloning, characterization, and chromosomal mapping of a human electroneutral Na+-driven ClHCO3 exchanger". J Biol Chem 276 (11): 8358–63. doi:10.1074/jbc.C000716200. PMID 11133997. 
  2. ^ "Entrez Gene: SLC4A8 solute carrier family 4, sodium bicarbonate cotransporter, member 8". 
  3. ^ Pushkin A, Abuladze N, Newman D, Muronets V, Sassani P, Tatishchev S et al. (March 2003). "The COOH termini of NBC3 and the 56-kDa H+-ATPase subunit are PDZ motifs involved in their interaction". Am. J. Physiol., Cell Physiol. 284 (3): C667–73. doi:10.1152/ajpcell.00225.2002. PMID 12444018. 
  4. ^ a b Park M, Ko SB, Choi JY, Muallem G, Thomas PJ, Pushkin A et al. (December 2002). "The cystic fibrosis transmembrane conductance regulator interacts with and regulates the activity of the HCO3 salvage transporter human Na+-HCO3 cotransport isoform 3". J. Biol. Chem. 277 (52): 50503–9. doi:10.1074/jbc.M201862200. PMID 12403779. 


Further reading[edit]

  • Soleimani M (2002). "Na+:HCO3 cs (NBC): expression and regulation in the kidney". J. Nephrol. 15 Suppl 5: S32–40. PMID 12027220. 
  • Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560. 
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
  • Loiselle FB, Morgan PE, Alvarez BV, Casey JR (2004). "Regulation of the human NBC3 Na+/HCO3 cotransporter by carbonic anhydrase II and PKA". Am. J. Physiol., Cell Physiol. 286 (6): C1423–33. doi:10.1152/ajpcell.00382.2003. PMID 14736710. 
  • Pushkin A, Abuladze N, Newman D, Muronets V, Sassani P, Tatishchev S et al. (2003). "The COOH termini of NBC3 and the 56-kDa H+-ATPase subunit are PDZ motifs involved in their interaction". Am. J. Physiol., Cell Physiol. 284 (3): C667–73. doi:10.1152/ajpcell.00225.2002. PMID 12444018. 
  • Park M, Ko SB, Choi JY, Muallem G, Thomas PJ, Pushkin A et al. (2003). "The cystic fibrosis transmembrane conductance regulator interacts with and regulates the activity of the HCO3 salvage transporter human Na+-HCO3 cotransport isoform 3". J. Biol. Chem. 277 (52): 50503–9. doi:10.1074/jbc.M201862200. PMID 12403779. 
  • Gresz V, Kwon TH, Vorum H, Zelles T, Kurtz I, Steward MC et al. (2002). "Immunolocalization of electroneutral Na+-HCO cotransporters in human and rat salivary glands". Am. J. Physiol. Gastrointest. Liver Physiol. 283 (2): G473–80. doi:10.1152/ajpgi.00421.2001. PMID 12121896. 
  • Amlal H, Burnham CE, Soleimani M (1999). "Characterization of Na+/HCO3 cotransporter isoform NBC-3". Am. J. Physiol. 276 (6 Pt 2): F903–13. PMID 10362779. 
  • Pushkin A, Abuladze N, Lee I, Newman D, Hwang J, Kurtz I (1999). "Cloning, tissue distribution, genomic organization, and functional characterization of NBC3, a new member of the sodium bicarbonate cotransporter family". J. Biol. Chem. 274 (23): 16569–75. doi:10.1074/jbc.274.23.16569. PMID 10347222. 
  • Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A et al. (1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.