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Solute carrier family 4, sodium bicarbonate cotransporter, member 8
Symbols SLC4A8 ; NBC3; NDCBE
External IDs OMIM605024 MGI1928745 HomoloGene68419 GeneCards: SLC4A8 Gene
RNA expression pattern
PBB GE SLC4A8 207056 s at tn.png
More reference expression data
Species Human Mouse
Entrez 9498 59033
Ensembl ENSG00000050438 ENSMUSG00000023032
UniProt Q2Y0W8 Q8JZR6
RefSeq (mRNA) NM_001039960 NM_001033218
RefSeq (protein) NP_001035049 NP_067505
Location (UCSC) Chr 12:
51.79 – 51.9 Mb
Chr 15:
100.76 – 100.82 Mb
PubMed search [1] [2]

Electroneutral sodium bicarbonate exchanger 1 is a protein that in humans is encoded by the SLC4A8 gene.[1][2]

See also[edit]


SLC4A8 has been shown to interact with Sodium-hydrogen antiporter 3 regulator 1[3][4] and Cystic fibrosis transmembrane conductance regulator.[4]


  1. ^ Grichtchenko II, Choi I, Zhong X, Bray-Ward P, Russell JM, Boron WF (May 2001). "Cloning, characterization, and chromosomal mapping of a human electroneutral Na+-driven ClHCO3 exchanger". J Biol Chem 276 (11): 8358–63. doi:10.1074/jbc.C000716200. PMID 11133997. 
  2. ^ "Entrez Gene: SLC4A8 solute carrier family 4, sodium bicarbonate cotransporter, member 8". 
  3. ^ Pushkin A, Abuladze N, Newman D, Muronets V, Sassani P, Tatishchev S, Kurtz I (March 2003). "The COOH termini of NBC3 and the 56-kDa H+-ATPase subunit are PDZ motifs involved in their interaction". Am. J. Physiol., Cell Physiol. 284 (3): C667–73. doi:10.1152/ajpcell.00225.2002. PMID 12444018. 
  4. ^ a b Park M, Ko SB, Choi JY, Muallem G, Thomas PJ, Pushkin A, Lee MS, Kim JY, Lee MG, Muallem S, Kurtz I (December 2002). "The cystic fibrosis transmembrane conductance regulator interacts with and regulates the activity of the HCO3 salvage transporter human Na+-HCO3 cotransport isoform 3". J. Biol. Chem. 277 (52): 50503–9. doi:10.1074/jbc.M201862200. PMID 12403779. 

Further reading[edit]