SLC6A14

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Solute carrier family 6 (amino acid transporter), member 14
Identifiers
Symbols SLC6A14 ; BMIQ11
External IDs OMIM300444 MGI1890216 HomoloGene38290 IUPHAR: 937 GeneCards: SLC6A14 Gene
RNA expression pattern
PBB GE SLC6A14 219795 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 11254 56774
Ensembl ENSG00000087916 ENSMUSG00000031089
UniProt Q9UN76 Q9JMA9
RefSeq (mRNA) NM_007231 NM_020049
RefSeq (protein) NP_009162 NP_064433
Location (UCSC) Chr HG1463_PATCH:
115.55 – 115.58 Mb
Chr X:
21.71 – 21.74 Mb
PubMed search [1] [2]

Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) is a protein that in humans is encoded by the SLC6A14 gene.[1][2]

Function[edit]

SLC6A14 is a member of the Na(+)- and Cl(−)-dependent neurotransmitter transporter family and transports both neutral and cationic amino acids in an Na(+)- and Cl(−)-dependent manner.[supplied by OMIM][2]

References[edit]

  1. ^ Sloan JL, Mager S (Sep 1999). "Cloning and functional expression of a human Na(+) and Cl(−)-dependent neutral and cationic amino acid transporter B(0+)". J Biol Chem 274 (34): 23740–5. doi:10.1074/jbc.274.34.23740. PMID 10446133. 
  2. ^ a b "Entrez Gene: SLC6A14 solute carrier family 6 (amino acid transporter), member 14". 

Further reading[edit]

  • Ohman M, Oksanen L, Kaprio J, Koskenvuo M, Mustajoki P, Rissanen A et al. (2000). "Genome-wide scan of obesity in Finnish sibpairs reveals linkage to chromosome Xq24". J. Clin. Endocrinol. Metab. 85 (9): 3183–90. doi:10.1210/jc.85.9.3183. PMID 10999806. 
  • Sloan JL, Grubb BR, Mager S (2003). "Expression of the amino acid transporter ATB 0+ in lung: possible role in luminal protein removal". Am. J. Physiol. Lung Cell Mol. Physiol. 284 (1): L39–49. doi:10.1152/ajplung.00164.2002 (inactive 2015-01-01). PMID 12388375. 
  • Suviolahti E, Oksanen LJ, Ohman M, Cantor RM, Ridderstrale M, Tuomi T et al. (2004). "The SLC6A14 gene shows evidence of association with obesity". J. Clin. Invest. 112 (11): 1762–72. doi:10.1172/JCI200317491. PMC 281637. PMID 14660752. 
  • Durand E, Boutin P, Meyre D, Charles MA, Clement K, Dina C et al. (2004). "Polymorphisms in the amino acid transporter solute carrier family 6 (neurotransmitter transporter) member 14 gene contribute to polygenic obesity in French Caucasians". Diabetes 53 (9): 2483–6. doi:10.2337/diabetes.53.9.2483. PMID 15331564. 
  • Gupta N, Miyauchi S, Martindale RG, Herdman AV, Podolsky R, Miyake K et al. (2005). "Upregulation of the amino acid transporter ATB0,+ (SLC6A14) in colorectal cancer and metastasis in humans". Biochim. Biophys. Acta 1741 (1–2): 215–23. doi:10.1016/j.bbadis.2005.04.002. PMID 15905073.