SLC6A15

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Solute carrier family 6 (neutral amino acid transporter), member 15
Identifiers
Symbols SLC6A15 ; NTT73; SBAT1; V7-3; hv7-3
External IDs OMIM607971 MGI2143484 HomoloGene18163 GeneCards: SLC6A15 Gene
Orthologs
Species Human Mouse
Entrez 55117 103098
Ensembl ENSG00000072041 ENSMUSG00000019894
UniProt Q9H2J7 Q8BG16
RefSeq (mRNA) NM_001146335 NM_001252330
RefSeq (protein) NP_001139807 NP_001239259
Location (UCSC) Chr 12:
85.25 – 85.31 Mb
Chr 10:
103.37 – 103.42 Mb
PubMed search [1] [2]

Solute carrier family 6 member 15 (SLC6A15) also known as the sodium-dependent neutral amino acid transporter B(0)AT2 (B0AT2)' is a protein that in humans is encoded by the SLC6A15 gene.[1]

Function[edit]

SLC6A15 shows structural characteristics of an Na+ and Cl-dependent neurotransmitter transporter, including 12 transmembrane (TM) domains, intracellular N and C termini, and large extracellular loops containing multiple N-glycosylation sites.[2]

Clinical relevance[edit]

Variants of this gene linked with depression are associated with reduced SLC6A15 expression in the human hippocampus, as well as decreased volume of this brain region.[3]

References[edit]

  1. ^ "Entrez Gene: solute carrier family 6 (neutral amino acid transporter)". 
  2. ^ Farmer MK, Robbins MJ, Medhurst AD, Campbell DA, Ellington K, Duckworth M, Brown AM, Middlemiss DN, Price GW, Pangalos MN (December 2000). "Cloning and characterization of human NTT5 and v7-3: two orphan transporters of the Na+/Cl -dependent neurotransmitter transporter gene family". Genomics 70 (2): 241–52. doi:10.1006/geno.2000.6387. PMID 11112352. 
  3. ^ Kohli MA, Lucae S, Saemann PG, Schmidt MV, Demirkan A, Hek K, Czamara D, Alexander M, Salyakina D, Ripke S, Hoehn D, Specht M, Menke A, Hennings J, Heck A, Wolf C, Ising M, Schreiber S, Czisch M, Müller MB, Uhr M, Bettecken T, Becker A, Schramm J, Rietschel M, Maier W, Bradley B, Ressler KJ, Nöthen MM, Cichon S, Craig IW, Breen G, Lewis CM, Hofman A, Tiemeier H, van Duijn CM, Holsboer F, Müller-Myhsok B, Binder EB (April 2011). "The Neuronal Transporter Gene SLC6A15 Confers Risk to Major Depression". Neuron 70 (2): 252–65. doi:10.1016/j.neuron.2011.04.005. PMC 3112053. PMID 21521612. 

Further reading[edit]

References[edit]