SLC7A11

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Solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
Identifiers
Symbols SLC7A11 ; CCBR1; xCT
External IDs OMIM607933 MGI1347355 HomoloGene22684 ChEMBL: 1075149 GeneCards: SLC7A11 Gene
RNA expression pattern
PBB GE SLC7A11 209921 at tn.png
PBB GE SLC7A11 207528 s at tn.png
PBB GE SLC7A11 217678 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 23657 26570
Ensembl ENSG00000151012 ENSMUSG00000027737
UniProt Q9UPY5 Q9WTR6
RefSeq (mRNA) NM_014331 NM_011990
RefSeq (protein) NP_055146 NP_036120
Location (UCSC) Chr 4:
139.09 – 139.16 Mb
Chr 3:
50.36 – 50.44 Mb
PubMed search [1] [2]

Cystine/glutamate transporter is an antiporter that in humans is encoded by the SLC7A11 gene.[1][2][3]

Function[edit]

SLC7A11 is a member of a heteromeric Na(+)-independent anionic amino acid transport system highly specific for cystine and glutamate. In this system, designated system Xc(-), the anionic form of cystine is transported in exchange for glutamate.[supplied by OMIM][3] SLC7A11 has also been termed 'xCT', especially in older literature.

Clinical significance[edit]

Recently, SLC7A11 has been shown to be involved in the cellular import of dimethylarsino-cysteine, an active metabolite of darinaparsin, an arsenic-based glutathion S-conjugate, in cancer cells.[4]

See also[edit]

References[edit]

  1. ^ Sato H, Tamba M, Ishii T, Bannai S (May 1999). "Cloning and expression of a plasma membrane cystine/glutamate exchange transporter composed of two distinct proteins". J Biol Chem 274 (17): 11455–8. doi:10.1074/jbc.274.17.11455. PMID 10206947. 
  2. ^ Wang H, Tamba M, Kimata M, Sakamoto K, Bannai S, Sato H (May 2003). "Expression of the activity of cystine/glutamate exchange transporter, system x(c)(-), by xCT and rBAT". Biochem Biophys Res Commun 305 (3): 611–8. doi:10.1016/S0006-291X(03)00808-8. PMID 12763038. 
  3. ^ a b "Entrez Gene: SLC7A11 solute carrier family 7, (cationic amino acid transporter, y+ system) member 11". 
  4. ^ Garnier N, Redstone GG, Dahabieh MS, Nichol JN, del Rincon SV, Gu Y, Bohle DS, Sun Y, Conklin DS, Mann KK, Miller WH (2014). "The novel arsenical darinaparsin is transported by cystine importing systems". Mol. Pharmacol. 85 (4): 576–85. doi:10.1124/mol.113.089433. PMID 24431147. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.