SLCO2A1

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Solute carrier organic anion transporter family, member 2A1
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols SLCO2A1 ; MATR1; OATP2A1; PGT; PHOAR2; SLC21A2
External IDs OMIM601460 HomoloGene38077 GeneCards: SLCO2A1 Gene
Orthologs
Species Human Mouse
Entrez 6578 24059
Ensembl ENSG00000174640 ENSMUSG00000032548
UniProt Q92959 Q9EPT5
RefSeq (mRNA) NM_005630 NM_033314
RefSeq (protein) NP_005621 NP_201571
Location (UCSC) Chr 3:
133.65 – 133.77 Mb
Chr 9:
103.01 – 103.09 Mb
PubMed search [1] [2]

Solute carrier organic anion transporter family, member 2A1 also known as the prostaglandin transporter (PGT) is a protein that in humans is encoded by the SLCO2A1 gene.[1]

This gene encodes a prostaglandin transporter that is a member of the 12-membrane-spanning organic anion-transporting polypeptide superfamily of transporters. The encoded protein may be involved in mediating the uptake and clearance of prostaglandins in numerous tissues.[1]

Clinical relevance[edit]

Mutations in this gene have been shown to cause primary hypertrophic osteoarthropathy.[2]

References[edit]

  1. ^ a b "Entrez Gene: Solute carrier organic anion transporter family, member 2A1". Retrieved 2011-12-30. 
  2. ^ Zhang Z, Xia W, He J, Zhang Z, Ke Y, Yue H, Wang C, Zhang H, Gu J, Hu W, Fu W, Hu Y, Li M, Liu Y (December 2011). "Exome Sequencing Identifies SLCO2A1 Mutations as a Cause of Primary Hypertrophic Osteoarthropathy". Am J Hum Genet 90 (1): 125–32. doi:10.1016/j.ajhg.2011.11.019. PMID 22197487. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.