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Secreted LY6/PLAUR domain containing 1
Symbols SLURP1 ; ANUP; ARS; ArsB; LY6LS; MDM
External IDs OMIM606119 MGI1930923 HomoloGene10710 GeneCards: SLURP1 Gene
RNA expression pattern
PBB GE SLURP1 214536 at tn.png
More reference expression data
Species Human Mouse
Entrez 57152 57277
Ensembl ENSG00000126233 ENSMUSG00000022596
UniProt P55000 Q9Z0K7
RefSeq (mRNA) NM_020427 NM_020519
RefSeq (protein) NP_065160 NP_065265
Location (UCSC) Chr 8:
143.82 – 143.82 Mb
Chr 15:
74.73 – 74.73 Mb
PubMed search [1] [2]

Secreted Ly-6/uPAR-related protein 1 is a protein that in humans is encoded by the SLURP1 gene.[1][2][3]

The protein encoded by this gene is a member of the Ly6/uPAR family but lacks a GPI-anchoring signal sequence. It is thought that this secreted protein contains antitumor activity. Mutations in this gene have been associated with Mal de Meleda, a rare autosomal recessive skin disorder. This gene maps to the same chromosomal region as several members of the Ly6/uPAR family of glycoprotein receptors.[3]


  1. ^ Fischer J, Bouadjar B, Heilig R, Huber M, Lefevre C, Jobard F, Macari F, Bakija-Konsuo A, Ait-Belkacem F, Weissenbach J, Lathrop M, Hohl D, Prud'homme JF (Apr 2001). "Mutations in the gene encoding SLURP-1 in Mal de Meleda". Hum Mol Genet 10 (8): 875–80. doi:10.1093/hmg/10.8.875. PMID 11285253. 
  2. ^ Adermann K, Wattler F, Wattler S, Heine G, Meyer M, Forssmann WG, Nehls M (Jul 1999). "Structural and phylogenetic characterization of human SLURP-1, the first secreted mammalian member of the Ly-6/uPAR protein superfamily". Protein Sci 8 (4): 810–9. doi:10.1110/ps.8.4.810. PMC 2144295. PMID 10211827. 
  3. ^ a b "Entrez Gene: SLURP1 secreted LY6/PLAUR domain containing 1". 

Further reading[edit]