SLURP1

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Secreted LY6/PLAUR domain containing 1
Identifiers
Symbols SLURP1 ; ANUP; ARS; ArsB; LY6LS; MDM
External IDs OMIM606119 MGI1930923 HomoloGene10710 GeneCards: SLURP1 Gene
RNA expression pattern
PBB GE SLURP1 214536 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 57152 57277
Ensembl ENSG00000126233 ENSMUSG00000022596
UniProt P55000 Q9Z0K7
RefSeq (mRNA) NM_020427 NM_020519
RefSeq (protein) NP_065160 NP_065265
Location (UCSC) Chr 8:
143.82 – 143.82 Mb
Chr 15:
74.73 – 74.73 Mb
PubMed search [1] [2]

Secreted Ly-6/uPAR-related protein 1 is a protein that in humans is encoded by the SLURP1 gene.[1][2][3]

The protein encoded by this gene is a member of the Ly6/uPAR family but lacks a GPI-anchoring signal sequence. It is thought that this secreted protein contains antitumor activity. Mutations in this gene have been associated with Mal de Meleda, a rare autosomal recessive skin disorder. This gene maps to the same chromosomal region as several members of the Ly6/uPAR family of glycoprotein receptors.[3]

References[edit]

  1. ^ Fischer J, Bouadjar B, Heilig R, Huber M, Lefevre C, Jobard F, Macari F, Bakija-Konsuo A, Ait-Belkacem F, Weissenbach J, Lathrop M, Hohl D, Prud'homme JF (Apr 2001). "Mutations in the gene encoding SLURP-1 in Mal de Meleda". Hum Mol Genet 10 (8): 875–80. doi:10.1093/hmg/10.8.875. PMID 11285253. 
  2. ^ Adermann K, Wattler F, Wattler S, Heine G, Meyer M, Forssmann WG, Nehls M (Jul 1999). "Structural and phylogenetic characterization of human SLURP-1, the first secreted mammalian member of the Ly-6/uPAR protein superfamily". Protein Sci 8 (4): 810–9. doi:10.1110/ps.8.4.810. PMC 2144295. PMID 10211827. 
  3. ^ a b "Entrez Gene: SLURP1 secreted LY6/PLAUR domain containing 1". 

Further reading[edit]