From Wikipedia, the free encyclopedia
Jump to: navigation, search
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
Symbols SMARCE1 ; BAF57
External IDs OMIM603111 MGI1927347 HomoloGene37727 GeneCards: SMARCE1 Gene
Species Human Mouse
Entrez 6605 57376
Ensembl ENSG00000073584 ENSMUSG00000037935
UniProt Q969G3 O54941
RefSeq (mRNA) NM_003079 NM_020618
RefSeq (protein) NP_003070 NP_065643
Location (UCSC) Chr 17:
38.78 – 38.8 Mb
Chr 11:
99.21 – 99.23 Mb
PubMed search [1] [2]

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 is a protein that in humans is encoded by the SMARCE1 gene.[1][2]

The protein encoded by this gene is part of the large ATP-dependent chromatin remodeling complex SWI/SNF, which is required for transcriptional activation of genes normally repressed by chromatin. The encoded protein, either alone or when in the SWI/SNF complex, can bind to 4-way junction DNA, which is thought to mimic the topology of DNA as it enters or exits the nucleosome. The protein contains a DNA-binding HMG domain, but disruption of this domain does not abolish the DNA-binding or nucleosome-displacement activities of the SWI/SNF complex. Unlike most of the SWI/SNF complex proteins, this protein has no yeast counterpart.[2]


SMARCE1 has been shown to interact with Estrogen receptor alpha,[3] SMARCB1[4][5] and SMARCA4.[4][5]


  1. ^ Wang W, Chi T, Xue Y, Zhou S, Kuo A, Crabtree GR (February 1998). "Architectural DNA binding by a high-mobility-group/kinesin-like subunit in mammalian SWI/SNF-related complexes". Proc Natl Acad Sci U S A 95 (2): 492–8. doi:10.1073/pnas.95.2.492. PMC 18447. PMID 9435219. 
  2. ^ a b "Entrez Gene: SMARCE1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1". 
  3. ^ Belandia, Borja; Orford Rob L; Hurst Helen C; Parker Malcolm G (August 2002). "Targeting of SWI/SNF chromatin remodelling complexes to estrogen-responsive genes". EMBO J. (England) 21 (15): 4094–103. doi:10.1093/emboj/cdf412. ISSN 0261-4189. PMC 126156. PMID 12145209. 
  4. ^ a b Wang, W; Côté J, Xue Y, Zhou S, Khavari P A, Biggar S R, Muchardt C, Kalpana G V, Goff S P, Yaniv M, Workman J L, Crabtree G R (October 1996). "Purification and biochemical heterogeneity of the mammalian SWI-SNF complex". EMBO J. (ENGLAND) 15 (19): 5370–82. ISSN 0261-4189. PMC 452280. PMID 8895581. 
  5. ^ a b Zhao, K; Wang W; Rando O J; Xue Y; Swiderek K; Kuo A; Crabtree G R (November 1998). "Rapid and phosphoinositol-dependent binding of the SWI/SNF-like BAF complex to chromatin after T lymphocyte receptor signaling". Cell (UNITED STATES) 95 (5): 625–36. doi:10.1016/S0092-8674(00)81633-5. ISSN 0092-8674. PMID 9845365. 

Further reading[edit]