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Structural maintenance of chromosomes 2
Symbols SMC2 ; CAP-E; CAPE; SMC-2; SMC2L1
External IDs OMIM605576 MGI106067 HomoloGene4705 GeneCards: SMC2 Gene
RNA expression pattern
PBB GE SMC2 213253 at tn.png
PBB GE SMC2 204240 s at tn.png
More reference expression data
Species Human Mouse
Entrez 10592 14211
Ensembl ENSG00000136824 ENSMUSG00000028312
UniProt O95347 Q8CG48
RefSeq (mRNA) NM_001042550 NM_008017
RefSeq (protein) NP_001036015 NP_032043
Location (UCSC) Chr 9:
106.86 – 106.9 Mb
Chr 4:
52.44 – 52.49 Mb
PubMed search [1] [2]

Structural maintenance of chromosomes protein 2 (SMC-2) also known as chromosome-associated protein E (CAP-E) is a protein that in humans is encoded by the SMC2 gene.[1][2]

SMC-2 is a subunit of condensin I and II, large protein complexes involved in chromosome condensation.


SMC2 has been shown to interact with DNMT3B.[3]


  1. ^ Schmiesing JA, Ball AR Jr, Gregson HC, Alderton JM, Zhou S, Yokomori K (Nov 1998). "Identification of two distinct human SMC protein complexes involved in mitotic chromosome dynamics". Proc Natl Acad Sci U S A 95 (22): 12906–11. doi:10.1073/pnas.95.22.12906. PMC 23650. PMID 9789013. 
  2. ^ "Entrez Gene: SMC2 structural maintenance of chromosomes 2". 
  3. ^ Geiman, Theresa M; Sankpal Umesh T, Robertson Andrea K, Chen Yue, Mazumdar Manjari, Heale Jason T, Schmiesing John A, Kim Wankee, Yokomori Kyoko, Zhao Yingming, Robertson Keith D (2004). "Isolation and characterization of a novel DNA methyltransferase complex linking DNMT3B with components of the mitotic chromosome condensation machinery". Nucleic Acids Res. (England) 32 (9): 2716–29. doi:10.1093/nar/gkh589. PMC 419596. PMID 15148359. 

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