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Protein SMTN PDB 2d87.png
PDB rendering based on 2d87.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols SMTN ; FLJ35168; FLJ35365; FLJ35620; FLJ38597
External IDs OMIM602127 MGI1354727 HomoloGene8482 GeneCards: SMTN Gene
RNA expression pattern
PBB GE SMTN 207390 s at tn.png
PBB GE SMTN 209427 at tn.png
More reference expression data
Species Human Mouse
Entrez 6525 29856
Ensembl ENSG00000183963 ENSMUSG00000020439
UniProt P53814 Q921U8
RefSeq (mRNA) NM_001207017 NM_001159284
RefSeq (protein) NP_001193946 NP_001152756
Location (UCSC) Chr 22:
31.46 – 31.5 Mb
Chr 11:
3.52 – 3.54 Mb
PubMed search [1] [2]

Smoothelin is a protein that in humans is encoded by the SMTN gene.[1][2][3]

This gene encodes a structural protein that is found exclusively in contractile smooth muscle cells. It associates with stress fibers and constitutes part of the cytoskeleton. This gene is localized to chromosome 22q12.3, distal to the TUPLE1 locus and outside the DiGeorge syndrome deletion. Alternative splicing of this gene results in three transcript variants.[3]


  1. ^ Engelen JJ, Esterling LE, Albrechts JC, Detera-Wadleigh SD, van Eys GJ (Sep 1997). "Assignment of the human gene for smoothelin (SMTN) to chromosome 22q12 by fluorescence in situ hybridization and radiation hybrid mapping". Genomics 43 (2): 245–7. doi:10.1006/geno.1997.9999. PMID 9244445. 
  2. ^ van der Loop FT, Schaart G, Timmer ED, Ramaekers FC, van Eys GJ (Sep 1996). "Smoothelin, a novel cytoskeletal protein specific for smooth muscle cells". J Cell Biol 134 (2): 401–11. doi:10.1083/jcb.134.2.401. PMC 2120883. PMID 8707825. 
  3. ^ a b "Entrez Gene: SMTN smoothelin". 

Further reading[edit]