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SMAD specific E3 ubiquitin protein ligase 1
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols SMURF1 ; KIAA1625
External IDs OMIM605568 MGI1923038 HomoloGene10712 GeneCards: SMURF1 Gene
Species Human Mouse
Entrez 57154 75788
Ensembl ENSG00000198742 ENSMUSG00000038780
UniProt Q9HCE7 Q9CUN6
RefSeq (mRNA) NM_001199847 NM_001038627
RefSeq (protein) NP_001186776 NP_001033716
Location (UCSC) Chr 7:
98.63 – 98.74 Mb
Chr 5:
144.88 – 144.97 Mb
PubMed search [1] [2]

E3 ubiquitin-protein ligase SMURF1 is an enzyme that in humans is encoded by the SMURF1 gene.[1][2]


This gene encodes a ubiquitin ligase that is specific for receptor-regulated SMAD proteins in the bone morphogenetic protein (BMP) pathway. A similar protein in Xenopus is involved in embryonic pattern formation. Alternative splicing results in multiple transcript variants encoding different isoforms. An additional transcript variant has been identified, but its full length sequence has not been determined.[2]


SMURF1 has been shown to interact with:


  1. ^ Zhu H, Kavsak P, Abdollah S, Wrana JL, Thomsen GH (Sep 1999). "A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation". Nature 400 (6745): 687–93. doi:10.1038/23293. PMID 10458166. 
  2. ^ a b "Entrez Gene: SMURF1 SMAD specific E3 ubiquitin protein ligase 1". 
  3. ^ Yamaguchi K, Ohara O, Ando A, Nagase T (Apr 2008). "Smurf1 directly targets hPEM-2, a GEF for Cdc42, via a novel combination of protein interaction modules in the ubiquitin-proteasome pathway". Biol. Chem. 389 (4): 405–13. doi:10.1515/BC.2008.036. PMID 18208356. 
  4. ^ Lu K, Yin X, Weng T, Xi S, Li L, Xing G, Cheng X, Yang X, Zhang L, He F (Aug 2008). "Targeting WW domains linker of HECT-type ubiquitin ligase Smurf1 for activation by CKIP-1". Nat. Cell Biol. 10 (8): 994–1002. doi:10.1038/ncb1760. PMID 18641638. 
  5. ^ Fukunaga E, Inoue Y, Komiya S, Horiguchi K, Goto K, Saitoh M, Miyazawa K, Koinuma D, Hanyu A, Imamura T (Dec 2008). "Smurf2 induces ubiquitin-dependent degradation of Smurf1 to prevent migration of breast cancer cells". J. Biol. Chem. 283 (51): 35660–7. doi:10.1074/jbc.M710496200. PMID 18927080. 

Further reading[edit]