From Wikipedia, the free encyclopedia
Jump to: navigation, search
SET and MYND domain containing 3
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols SMYD3 ; KMT3E; ZMYND1; ZNFN3A1; bA74P14.1
External IDs OMIM608783 MGI1916976 HomoloGene41491 GeneCards: SMYD3 Gene
EC number
RNA expression pattern
PBB GE SMYD3 218788 s at tn.png
More reference expression data
Species Human Mouse
Entrez 64754 69726
Ensembl ENSG00000185420 ENSMUSG00000055067
UniProt Q9H7B4 Q9CWR2
RefSeq (mRNA) NM_001167740 NM_027188
RefSeq (protein) NP_001161212 NP_081464
Location (UCSC) Chr 1:
245.91 – 246.67 Mb
Chr 1:
178.95 – 179.52 Mb
PubMed search [1] [2]

SET and MYND domain-containing protein 3 is a protein that in humans is encoded by the SMYD3 gene.[1]

SMYD3 is a histone methyltransferase that plays a role in transcriptional regulation as a member of an RNA polymerase complex.[1]

Model organisms[edit]

Model organisms have been used in the study of SMYD3 function. A conditional knockout mouse line, called Smyd3tm2a(KOMP)Wtsi[6][7] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists — at the Wellcome Trust Sanger Institute.[8][9][10]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[4][11] Twenty three tests were carried out on homozygous mutant adult mice, however no significant abnormalities were observed.[4]


SMYD3 has been shown to interact with Heat shock protein 90kDa alpha (cytosolic), member A1[12] and POLR2A.[12]

SMYD3 trimethylates a lysine residue on MAP3K2, which causes crosstalk into the MAP kinase signaling pathway in Ras-driven cancers.[13]


  1. ^ a b "Entrez Gene: SMYD3 SET and MYND domain containing 3". 
  2. ^ "Salmonella infection data for Smyd3". Wellcome Trust Sanger Institute. 
  3. ^ "Citrobacter infection data for Smyd3". Wellcome Trust Sanger Institute. 
  4. ^ a b c Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica 88 (S248). doi:10.1111/j.1755-3768.2010.4142.x. 
  5. ^ Mouse Resources Portal, Wellcome Trust Sanger Institute.
  6. ^ "International Knockout Mouse Consortium". 
  7. ^ "Mouse Genome Informatics". 
  8. ^ Skarnes, W. C.; Rosen, B.; West, A. P.; Koutsourakis, M.; Bushell, W.; Iyer, V.; Mujica, A. O.; Thomas, M.; Harrow, J.; Cox, T.; Jackson, D.; Severin, J.; Biggs, P.; Fu, J.; Nefedov, M.; De Jong, P. J.; Stewart, A. F.; Bradley, A. (2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature 474 (7351): 337–342. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.  edit
  9. ^ Dolgin E (June 2011). "Mouse library set to be knockout". Nature 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718. 
  10. ^ Collins FS, Rossant J, Wurst W (January 2007). "A mouse for all reasons". Cell 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247. 
  11. ^ van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism.". Genome Biol 12 (6): 224. doi:10.1186/gb-2011-12-6-224. PMC 3218837. PMID 21722353. 
  12. ^ a b Hamamoto, Ryuji; Furukawa Yoichi; Morita Masashi; Iimura Yuko; Silva Fabio Pittella; Li Meihua; Yagyu Ryuichiro; Nakamura Yusuke (August 2004). "SMYD3 encodes a histone methyltransferase involved in the proliferation of cancer cells". Nat. Cell Biol. (England) 6 (8): 731–40. doi:10.1038/ncb1151. ISSN 1465-7392. PMID 15235609. 
  13. ^ Mazur, Pawel K.; Nicolas Reynoird; Purvesh Khatri; Pascal W. T. C. Jansen; Alex W. Wilkinson; Shichong Liu; Olena Barbash; Glenn S. Van Aller; Michael Huddleston; Dashyant Dhanak; Peter J. Tummino; Ryan G. Kruger; Benjamin A. Garcia; Atul J. Butte; Michiel Vermeulen; Julien Sage; Or Gozani (June 2014). "SMYD3 links lysine methylation of MAP3K2 to Ras-driven cancer". Nature 510 (7504): 283–87. doi:10.1038/nature13320. PMID 24847881. 

Further reading[edit]