SNAI1

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Snail homolog 1 (Drosophila)
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols SNAI1 ; SLUGH2; SNA; SNAH; SNAIL; SNAIL1; dJ710H13.1
External IDs OMIM604238 MGI98330 HomoloGene4363 GeneCards: SNAI1 Gene
RNA expression pattern
PBB GE SNAI1 219480 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 6615 20613
Ensembl ENSG00000124216 ENSMUSG00000042821
UniProt O95863 Q02085
RefSeq (mRNA) NM_005985 NM_011427
RefSeq (protein) NP_005976 NP_035557
Location (UCSC) Chr 20:
48.6 – 48.61 Mb
Chr 2:
167.54 – 167.54 Mb
PubMed search [1] [2]

Zinc finger protein SNAI1 is a protein that in humans is encoded by the SNAI1 gene.[1][2]

Function[edit]

The Drosophila embryonic protein SNAI1, commonly known as Snail, is a zinc finger transcriptional repressor which downregulates the expression of ectodermal genes within the mesoderm. The nuclear protein encoded by this gene is structurally similar to the Drosophila snail protein, and is also thought to be critical for mesoderm formation in the developing embryo. At least two variants of a similar processed pseudogene have been found on chromosome 2.[2]

Clinical significance[edit]

SNAIL gene may show a role in recurrence of breast cancer by downregulating E-cadherin and inducing an epithelial to mesenchymal transition.[3]

Interactions[edit]

SNAI1 has been shown to interact with CTDSPL,[4] CTDSP1[4] and CTDSP2.[4]

References[edit]

  1. ^ Paznekas WA, Okajima K, Schertzer M, Wood S, Jabs EW (February 2000). "Genomic organization, expression, and chromosome location of the human SNAIL gene (SNAI1) and a related processed pseudogene (SNAI1P)". Genomics 62 (1): 42–9. doi:10.1006/geno.1999.6010. PMID 10585766. 
  2. ^ a b "Entrez Gene: SNAI1 snail homolog 1 (Drosophila)". 
  3. ^ Davidson NE, Sukumar S (September 2005). "Of Snail, mice, and women". Cancer Cell 8 (3): 173–4. doi:10.1016/j.ccr.2005.08.006. PMID 16169460. 
  4. ^ a b c Wu Y, Evers BM, Zhou BP (January 2009). "Small C-terminal domain phosphatase enhances snail activity through dephosphorylation". J. Biol. Chem. 284 (1): 640–8. doi:10.1074/jbc.M806916200. PMC 2610500. PMID 19004823. 

Further reading[edit]