SNAI2

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Snail homolog 2 (Drosophila)
Identifiers
Symbols SNAI2 ; SLUG; SLUGH1; SNAIL2; WS2D
External IDs OMIM602150 MGI1096393 HomoloGene31127 GeneCards: SNAI2 Gene
RNA expression pattern
PBB GE SNAI2 213139 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 6591 20583
Ensembl ENSG00000019549 ENSMUSG00000022676
UniProt O43623 P97469
RefSeq (mRNA) NM_003068 NM_011415
RefSeq (protein) NP_003059 NP_035545
Location (UCSC) Chr 8:
49.83 – 49.83 Mb
Chr 16:
14.71 – 14.71 Mb
PubMed search [1] [2]

Zinc finger protein SNAI2 is a protein that in humans is encoded by the SNAI2 gene.[1][2][3]

This gene encodes a member of the Snail family of C2H2-type zinc finger transcription factors. The encoded protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress E-cadherin transcription in breast carcinoma. This protein is involved in epithelial-mesenchymal transitions and has antiapoptotic activity. Mutations in this gene may be associated with sporadic cases of neural tube defects.[3]

References[edit]

  1. ^ Rhim H, Savagner P, Thibaudeau G, Thiery JP, Pavan WJ (Jan 1998). "Localization of a neural crest transcription factor, Slug, to mouse chromosome 16 and human chromosome 8". Mamm Genome 8 (11): 872–3. doi:10.1007/s003359900601. PMID 9337409. 
  2. ^ Cohen ME, Yin M, Paznekas WA, Schertzer M, Wood S, Jabs EW (Oct 1998). "Human SLUG gene organization, expression, and chromosome map location on 8q". Genomics 51 (3): 468–71. doi:10.1006/geno.1998.5367. PMID 9721220. 
  3. ^ a b "Entrez Gene: SNAI2 snail homolog 2 (Drosophila)". 

Further reading[edit]