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Snail family zinc finger 2
External IDs OMIM602150 MGI1096393 HomoloGene31127 GeneCards: SNAI2 Gene
RNA expression pattern
PBB GE SNAI2 213139 at tn.png
More reference expression data
Species Human Mouse
Entrez 6591 20583
Ensembl ENSG00000019549 ENSMUSG00000022676
UniProt O43623 P97469
RefSeq (mRNA) NM_003068 NM_011415
RefSeq (protein) NP_003059 NP_035545
Location (UCSC) Chr 8:
49.83 – 49.83 Mb
Chr 16:
14.71 – 14.71 Mb
PubMed search [1] [2]

Zinc finger protein SNAI2 is a protein that in humans is encoded by the SNAI2 gene.[1][2][3]

This gene encodes a member of the Snail family of C2H2-type zinc finger transcription factors. The encoded protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress E-cadherin transcription in breast carcinoma. This protein is involved in epithelial-mesenchymal transitions and has antiapoptotic activity. Mutations in this gene may be associated with sporadic cases of neural tube defects.[3]


  1. ^ Rhim H, Savagner P, Thibaudeau G, Thiery JP, Pavan WJ (Jan 1998). "Localization of a neural crest transcription factor, Slug, to mouse chromosome 16 and human chromosome 8". Mamm Genome 8 (11): 872–3. doi:10.1007/s003359900601. PMID 9337409. 
  2. ^ Cohen ME, Yin M, Paznekas WA, Schertzer M, Wood S, Jabs EW (Oct 1998). "Human SLUG gene organization, expression, and chromosome map location on 8q". Genomics 51 (3): 468–71. doi:10.1006/geno.1998.5367. PMID 9721220. 
  3. ^ a b "Entrez Gene: SNAI2 snail homolog 2 (Drosophila)". 

Further reading[edit]