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Small nuclear ribonucleoprotein polypeptide B
Protein SNRPB2 PDB 1a9n.png
PDB rendering based on 1a9n.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols SNRPB2 ; Msl1
External IDs OMIM603520 MGI104805 HomoloGene37728 GeneCards: SNRPB2 Gene
RNA expression pattern
PBB GE SNRPB2 202505 at tn.png
More reference expression data
Species Human Mouse
Entrez 6629 20639
Ensembl ENSG00000125870 ENSMUSG00000008333
UniProt P08579 Q9CQI7
RefSeq (mRNA) NM_003092 NM_021335
RefSeq (protein) NP_003083 NP_067310
Location (UCSC) Chr 20:
16.71 – 16.72 Mb
Chr 2:
143.06 – 143.07 Mb
PubMed search [1] [2]

U2 small nuclear ribonucleoprotein B is a protein that in humans is encoded by the SNRPB2 gene.[1][2]

The protein encoded by this gene associates with stem loop IV of U2 small nuclear ribonucleoprotein (U2 snRNP) in the presence of snRNP-A'. The encoded protein may play a role in pre-mRNA splicing. Autoantibodies from patients with systemic lupus erythematosus frequently recognize epitopes on the encoded protein. Two transcript variants encoding the same protein have been found for this gene.[2]


  1. ^ Habets WJ, Sillekens PT, Hoet MH, Schalken JA, Roebroek AJ, Leunissen JA, van de Ven WJ, van Venrooij WJ (May 1987). "Analysis of a cDNA clone expressing a human autoimmune antigen: full-length sequence of the U2 small nuclear RNA-associated B" antigen". Proc Natl Acad Sci U S A 84 (8): 2421–5. doi:10.1073/pnas.84.8.2421. PMC 304663. PMID 2951739. 
  2. ^ a b "Entrez Gene: SNRPB2 small nuclear ribonucleoprotein polypeptide B". 

Further reading[edit]