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Small nuclear ribonucleoprotein D3 polypeptide 18kDa
Protein SNRPD3 PDB 1d3b.png
PDB rendering based on 1d3b.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols SNRPD3 ; SMD3; Sm-D3
External IDs OMIM601062 MGI1914582 HomoloGene128323 GeneCards: SNRPD3 Gene
Species Human Mouse
Entrez 6634 67332
Ensembl ENSG00000100028 ENSMUSG00000020180
UniProt P62318 P62320
RefSeq (mRNA) NM_004175 NM_026095
RefSeq (protein) NP_004166 NP_080371
Location (UCSC) Chr 22:
24.95 – 25.01 Mb
Chr 10:
75.52 – 75.54 Mb
PubMed search [1] [2]

Small nuclear ribonucleoprotein Sm D3 is a protein that in humans is encoded by the SNRPD3 gene.[1][2][3]

The protein encoded by this gene belongs to the small nuclear ribonucleoprotein core protein family. It is required for pre-mRNA splicing and small nuclear ribonucleoprotein biogenesis.[3]


SNRPD3 has been shown to interact with DDX20,[4] CLNS1A,[5] CDC5L[6] and Protein arginine methyltransferase 5.[5]


  1. ^ Lehmeier T, Foulaki K, Luhrmann R (January 1991). "Evidence for three distinct D proteins, which react differentially with anti-Sm autoantibodies, in the cores of the major snRNPs U1, U2, U4/U6 and U5". Nucleic Acids Res 18 (22): 6475–84. doi:10.1093/nar/18.22.6475. PMC 332598. PMID 1701240. 
  2. ^ Lehmeier T, Raker V, Hermann H, Luhrmann R (January 1995). "cDNA cloning of the Sm proteins D2 and D3 from human small nuclear ribonucleoproteins: evidence for a direct D1-D2 interaction". Proc Natl Acad Sci U S A 91 (25): 12317–21. doi:10.1073/pnas.91.25.12317. PMC 45428. PMID 7527560. 
  3. ^ a b "Entrez Gene: SNRPD3 small nuclear ribonucleoprotein D3 polypeptide 18kDa". 
  4. ^ Charroux, B; Pellizzoni L, Perkinson R A, Shevchenko A, Mann M, Dreyfuss G (Dec 1999). "Gemin3: A Novel Dead Box Protein That Interacts with Smn, the Spinal Muscular Atrophy Gene Product, and Is a Component of Gems". J. Cell Biol. (UNITED STATES) 147 (6): 1181–94. doi:10.1083/jcb.147.6.1181. ISSN 0021-9525. PMC 2168095. PMID 10601333. 
  5. ^ a b Friesen, W J; Paushkin S, Wyce A, Massenet S, Pesiridis G S, Van Duyne G, Rappsilber J, Mann M, Dreyfuss G (Dec 2001). "The Methylosome, a 20S Complex Containing JBP1 and pICln, Produces Dimethylarginine-Modified Sm Proteins". Mol. Cell. Biol. (United States) 21 (24): 8289–300. doi:10.1128/MCB.21.24.8289-8300.2001. ISSN 0270-7306. PMC 99994. PMID 11713266. 
  6. ^ Ajuh, P; Kuster B, Panov K, Zomerdijk J C, Mann M, Lamond A I (Dec 2000). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry". EMBO J. (ENGLAND) 19 (23): 6569–81. doi:10.1093/emboj/19.23.6569. ISSN 0261-4189. PMC 305846. PMID 11101529. 

Further reading[edit]