SNX1

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Sorting nexin 1
PDB 2i4k EBI.png
PDB rendering based on 2i4k.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols SNX1 ; HsT17379; VPS5
External IDs OMIM601272 MGI1928395 HomoloGene99716 GeneCards: SNX1 Gene
Orthologs
Species Human Mouse
Entrez 6642 56440
Ensembl ENSG00000028528 ENSMUSG00000032382
UniProt Q13596 Q9WV80
RefSeq (mRNA) NM_001242933 NM_019727
RefSeq (protein) NP_001229862 NP_062701
Location (UCSC) Chr 15:
64.39 – 64.44 Mb
Chr 9:
66.09 – 66.13 Mb
PubMed search [1] [2]

Sorting nexin-1 is a protein that in humans is encoded by the SNX1 gene. The protein encoded by this gene is a sorting nexin.[1] SNX1 is a component of the retromer complex.[2][3]

Function[edit]

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This endosomal protein regulates the cell-surface expression of epidermal growth factor receptor. This protein also has a role in sorting protease-activated receptor-1 from early endosomes to lysosomes. This protein may form oligomeric complexes with other family members.[4]

References[edit]

  1. ^ Kurten RC, Cadena DL, Gill GN (May 1996). "Enhanced degradation of EGF receptors by a sorting nexin, SNX1". Science 272 (5264): 1008–10. doi:10.1126/science.272.5264.1008. PMID 8638121. 
  2. ^ Vergés M (2008). "Retromer: multipurpose sorting and specialization in polarized transport". Int Rev Cell Mol Biol 271: 153–98. doi:10.1016/S1937-6448(08)01204-5. PMID 19081543. 
  3. ^ Bonifacino JS, Hurley JH (August 2008). "Retromer". Curr. Opin. Cell Biol. 20 (4): 427–36. doi:10.1016/j.ceb.2008.03.009. PMC 2833274. PMID 18472259. 
  4. ^ "Entrez Gene: sorting nexin 1". 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.