SNX13

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Sorting nexin 13
Identifiers
Symbols SNX13 ; RGS-PX1
External IDs OMIM606589 MGI2661416 HomoloGene41011 GeneCards: SNX13 Gene
RNA expression pattern
PBB GE SNX13 213292 s at tn.png
PBB GE SNX13 215820 x at tn.png
PBB GE SNX13 215366 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 23161 217463
Ensembl ENSG00000071189 ENSMUSG00000020590
UniProt Q9Y5W8 Q6PHS6
RefSeq (mRNA) NM_015132 NM_001014973
RefSeq (protein) NP_055947 NP_001014973
Location (UCSC) Chr 7:
17.83 – 17.98 Mb
Chr 12:
35.05 – 35.15 Mb
PubMed search [1] [2]

Sorting nexin-13 is a protein that in humans is encoded by the SNX13 gene.[1][2][3]

This gene encodes a PHOX domain- and RGS domain-containing protein that belongs to the sorting nexin (SNX) family and the regulator of G protein signaling (RGS) family. The PHOX domain is a phosphoinositide binding domain, and the SNX family members are involved in intracellular trafficking. The RGS family members are regulatory molecules that act as GTPase activating proteins for G alpha subunits of heterotrimeric G proteins. The RGS domain of this protein interacts with G alpha(s), accelerates its GTP hydrolysis, and attenuates G alpha(s)-mediated signaling. Overexpression of this protein delayes lysosomal degradation of the epidermal growth factor receptor. Because of its bifunctional role, this protein may link heterotrimeric G protein signaling and vesicular trafficking.[3]

References[edit]

  1. ^ Teasdale RD, Loci D, Houghton F, Karlsson L, Gleeson PA (Aug 2001). "A large family of endosome-localized proteins related to sorting nexin 1". Biochem J 358 (Pt 1): 7–16. doi:10.1042/0264-6021:3580007. PMC 1222026. PMID 11485546. 
  2. ^ Zheng B, Ma YC, Ostrom RS, Lavoie C, Gill GN, Insel PA, Huang XY, Farquhar MG (Nov 2001). "RGS-PX1, a GAP for GalphaS and sorting nexin in vesicular trafficking". Science 294 (5548): 1939–42. doi:10.1126/science.1064757. PMID 11729322. 
  3. ^ a b "Entrez Gene: SNX13 sorting nexin 13". 

Further reading[edit]