This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. Overexpression of this gene results in a decrease in the processing of insulin and hepatocyte growth factor receptors to their mature subunits. This decrease is caused by the mislocalization of furin, the endoprotease responsible for cleavage of insulin and hepatocyte growth factor receptors. This protein is involved in endosomal trafficking from the plasma membrane to recycling endosomes or the trans-Golgi network. This gene encodes two transcript variants encoding distinct isoforms.
^Barr VA, Phillips SA, Taylor SI, Haft CR (Mar 2001). "Overexpression of a novel sorting nexin, SNX15, affects endosome morphology and protein trafficking". Traffic1 (11): 904–16. doi:10.1034/j.1600-0854.2000.011109.x. PMID11208079.Cite uses deprecated parameters (help)
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID9373149.
Phillips SA, Barr VA, Haft DH, et al. (2001). "Identification and characterization of SNX15, a novel sorting nexin involved in protein trafficking". J. Biol. Chem.276 (7): 5074–84. doi:10.1074/jbc.M004671200. PMID11085978.