SNX15

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Sorting nexin 15
Identifiers
Symbols SNX15 ; HSAF001435
External IDs OMIM605964 MGI1916274 HomoloGene12294 GeneCards: SNX15 Gene
Orthologs
Species Human Mouse
Entrez 29907 69024
Ensembl ENSG00000110025 ENSMUSG00000024787
UniProt Q9NRS6 Q91WE1
RefSeq (mRNA) NM_013306 NM_026912
RefSeq (protein) NP_037438 NP_081188
Location (UCSC) Chr 11:
64.78 – 64.81 Mb
Chr 19:
6.12 – 6.13 Mb
PubMed search [1] [2]

Sorting nexin-15 is a protein that in humans is encoded by the SNX15 gene.[1][2]

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. Overexpression of this gene results in a decrease in the processing of insulin and hepatocyte growth factor receptors to their mature subunits. This decrease is caused by the mislocalization of furin, the endoprotease responsible for cleavage of insulin and hepatocyte growth factor receptors. This protein is involved in endosomal trafficking from the plasma membrane to recycling endosomes or the trans-Golgi network. This gene encodes two transcript variants encoding distinct isoforms.[2]

References[edit]

  1. ^ Barr VA, Phillips SA, Taylor SI, Haft CR (Mar 2001). "Overexpression of a novel sorting nexin, SNX15, affects endosome morphology and protein trafficking". Traffic 1 (11): 904–16. doi:10.1034/j.1600-0854.2000.011109.x. PMID 11208079. 
  2. ^ a b "Entrez Gene: SNX15 sorting nexin 15". 

Further reading[edit]