SNX17

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Sorting nexin 17
Protein SNX17 PDB 3FOG.png
Rendering based on PDB 3FOG.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols SNX17 ; KIAA0064
External IDs OMIM605963 MGI2387801 HomoloGene8838 GeneCards: SNX17 Gene
RNA expression pattern
PBB GE SNX17 200991 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 9784 266781
Ensembl ENSG00000115234 ENSMUSG00000029146
UniProt Q15036 Q8BVL3
RefSeq (mRNA) NM_001267059 NM_153680
RefSeq (protein) NP_001253988 NP_710147
Location (UCSC) Chr 2:
27.59 – 27.6 Mb
Chr 5:
31.19 – 31.2 Mb
PubMed search [1] [2]

Sorting nexin-17 is a protein that in humans is encoded by the SNX17 gene.[1][2][3]

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members, but contains a B41 domain. This protein interacts with the cytoplasmic domain of P-selectin, and may function in the intracellular trafficking of P-selectin.[3]

Interactions[edit]

SNX17 has been shown to interact with Low density lipoprotein receptor-related protein 8[1] and LDL receptor.[1]

References[edit]

  1. ^ a b c Stockinger W, Sailler B, Strasser V, Recheis B, Fasching D, Kahr L, Schneider WJ, Nimpf J (Aug 2002). "The PX-domain protein SNX17 interacts with members of the LDL receptor family and modulates endocytosis of the LDL receptor". EMBO J 21 (16): 4259–67. doi:10.1093/emboj/cdf435. PMC 126172. PMID 12169628. 
  2. ^ Knauth P, Schluter T, Czubayko M, Kirsch C, Florian V, Schreckenberger S, Hahn H, Bohnensack R (Mar 2005). "Functions of sorting nexin 17 domains and recognition motif for P-selectin trafficking". J Mol Biol 347 (4): 813–25. doi:10.1016/j.jmb.2005.02.004. PMID 15769472. 
  3. ^ a b "Entrez Gene: SNX17 sorting nexin 17". 

Further reading[edit]