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Sorting nexin family member 21
Symbols SNX21 ; C20orf161; PP3993; SNX-L; dJ337O18.4
External IDs MGI1917729 HomoloGene43132 GeneCards: SNX21 Gene
Species Human Mouse
Entrez 90203 101113
Ensembl ENSG00000124104 ENSMUSG00000050373
UniProt Q969T3 Q149Q9
RefSeq (mRNA) NM_001042632 NM_133924
RefSeq (protein) NP_001036097 NP_598685
Location (UCSC) Chr 20:
44.46 – 44.47 Mb
Chr 2:
164.79 – 164.79 Mb
PubMed search [1] [2]

Sorting nexin-21 is a protein that in humans is encoded by the SNX21 gene.[1][2][3]

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members. The specific function of this protein has not been determined. Multiple transcript variants encoding distinct isoforms have been identified for this gene.[3]


  1. ^ Worby CA, Dixon JE (Dec 2002). "Sorting out the cellular functions of sorting nexins". Nat Rev Mol Cell Biol 3 (12): 919–31. doi:10.1038/nrm974. PMID 12461558. 
  2. ^ Zeng W, Yuan W, Wang Y, Jiao W, Zhu Y, Huang C, Li D, Li Y, Zhu C, Wu X, Liu M (Dec 2002). "Expression of a novel member of sorting nexin gene family, SNX-L, in human liver development". Biochem Biophys Res Commun 299 (4): 542–8. doi:10.1016/S0006-291X(02)02695-5. PMID 12459172. 
  3. ^ a b "Entrez Gene: SNX21 sorting nexin family member 21". 

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