SNX27

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Sorting nexin family member 27
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols SNX27 ; MRT1; MY014
External IDs OMIM611541 MGI1923992 HomoloGene12797 GeneCards: SNX27 Gene
RNA expression pattern
PBB GE SNX27 221006 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 81609 76742
Ensembl ENSG00000143376 ENSMUSG00000028136
UniProt Q96L92 Q3UHD6
RefSeq (mRNA) NM_030918 NM_001082484
RefSeq (protein) NP_112180 NP_001075953
Location (UCSC) Chr 1:
151.58 – 151.67 Mb
Chr 3:
94.5 – 94.58 Mb
PubMed search [1] [2]

Sorting nexin family member 27, also known as SNX27, is a human gene.[1]

This gene encodes a member of the sorting nexin family, a diverse group of cytoplasmic and membrane-associated proteins involved in endocytosis of plasma membrane receptors and protein trafficking through these compartments. All members of this protein family contain a phosphoinositide binding domain (PX domain). A highly similar protein in mouse is responsible for the specific recruitment of an isoform of the serotonin 5-hydroxytryptamine 4 receptor into early endosomes, suggesting the analogous role for the human protein.[1] "Loss of sorting nexin 27 contributes to excitatory synaptic dysfunction by modulating glutamate receptor recycling in Down's syndrome" by Xin Wang et al. was published in Nature Medicine on March 24, 2013. [3]

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