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Sorting nexin 4
Symbols SNX4 ; ATG24B
External IDs OMIM605931 MGI1916400 HomoloGene36143 GeneCards: SNX4 Gene
RNA expression pattern
PBB GE SNX4 212652 s at tn.png
PBB GE SNX4 205329 s at tn.png
More reference expression data
Species Human Mouse
Entrez 8723 69150
Ensembl ENSG00000114520 ENSMUSG00000022808
UniProt O95219 Q91YJ2
RefSeq (mRNA) NM_003794 NM_080557
RefSeq (protein) NP_003785 NP_542124
Location (UCSC) Chr 3:
125.17 – 125.24 Mb
Chr 16:
33.25 – 33.3 Mb
PubMed search [1] [2]

Sorting nexin-4 is a protein that in humans is encoded by the SNX4 gene.[1][2]

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein associated with the long isoform of the leptin receptor and with receptor tyrosine kinases for platelet-derived growth factor, insulin, and epidermal growth factor in cell cultures, but its function is unknown. This protein may form oligomeric complexes with family members.[2]


SNX4 has been shown to interact with BIN1.[3]


  1. ^ Haft CR, de la Luz Sierra M, Barr VA, Haft DH, Taylor SI (Dec 1998). "Identification of a family of sorting nexin molecules and characterization of their association with receptors". Mol Cell Biol 18 (12): 7278–87. PMC 109309. PMID 9819414. 
  2. ^ a b "Entrez Gene: SNX4 sorting nexin 4". 
  3. ^ Leprince, Corinne; Le Scolan Erwan; Meunier Brigitte; Fraisier Vincent; Brandon Nathalie; De Gunzburg Jean; Camonis Jacques (May 2003). "Sorting nexin 4 and amphiphysin 2, a new partnership between endocytosis and intracellular trafficking". J. Cell. Sci. (England) 116 (Pt 10): 1937–48. doi:10.1242/jcs.00403. ISSN 0021-9533. PMID 12668730. 

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