SNX9

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Sorting nexin 9
Protein SNX9 PDB 2RAI.png
Rendering based on PDB 2RAI.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols SNX9 ; MST155; MSTP155; SDP1; SH3PX1; SH3PXD3A; WISP
External IDs OMIM605952 MGI1913866 HomoloGene49454 GeneCards: SNX9 Gene
RNA expression pattern
PBB GE SNX9 gnf1h00218 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 51429 66616
Ensembl ENSG00000130340 ENSMUSG00000002365
UniProt Q9Y5X1 Q91VH2
RefSeq (mRNA) NM_016224 NM_025664
RefSeq (protein) NP_057308 NP_079940
Location (UCSC) Chr 6:
158.24 – 158.37 Mb
Chr 17:
5.84 – 5.93 Mb
PubMed search [1] [2]

Sorting nexin-9 is a protein that in humans is encoded by the SNX9 gene.[1][2][3]

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members, but does contain an SH3 domain near its N-terminus. This protein interacts with the cytoplasmic domains of the precursor but not the processed forms of a disintegrin and metalloprotease domain 9 and 15. This protein binds the beta-appendage domain of adaptor protein 2 and may function to assist adaptor protein 2 in its role at the plasma membrane. This protein interacts with activated Cdc42-associated kinase-2 to regulate the degradation of epidermal growth factor receptor protein.[3]

Interactions[edit]

SNX9 has been shown to interact with ADAM9,[1] DNM2[4] and ADAM15.[1]

References[edit]

  1. ^ a b c Howard L, Nelson KK, Maciewicz RA, Blobel CP (Dec 1999). "Interaction of the metalloprotease disintegrins MDC9 and MDC15 with two SH3 domain-containing proteins, endophilin I and SH3PX1". J Biol Chem 274 (44): 31693–9. doi:10.1074/jbc.274.44.31693. PMID 10531379. 
  2. ^ Yarar D, Waterman-Storer CM, Schmid SL (Jul 2007). "SNX9 couples actin assembly to phosphoinositide signals and is required for membrane remodeling during endocytosis". Dev Cell 13 (1): 43–56. doi:10.1016/j.devcel.2007.04.014. PMID 17609109. 
  3. ^ a b "Entrez Gene: SNX9 sorting nexin 9". 
  4. ^ Lundmark, Richard; Carlsson Sven R (Nov 2003). "Sorting nexin 9 participates in clathrin-mediated endocytosis through interactions with the core components". J. Biol. Chem. (United States) 278 (47): 46772–81. doi:10.1074/jbc.M307334200. ISSN 0021-9258. PMID 12952949. 

Further reading[edit]