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Suppressor of cytokine signaling 6
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols SOCS6 ; CIS-4; CIS4; HSPC060; SOCS-4; SOCS-6; SOCS4; SSI4; STAI4; STATI4
External IDs OMIM605118 MGI1924885 HomoloGene3120 GeneCards: SOCS6 Gene
RNA expression pattern
PBB GE SOCS6 214462 at tn.png
PBB GE SOCS6 206020 at tn.png
More reference expression data
Species Human Mouse
Entrez 9306 54607
Ensembl ENSG00000170677 ENSMUSG00000056153
UniProt O14544 Q9JLY0
RefSeq (mRNA) NM_004232 NM_018821
RefSeq (protein) NP_004223 NP_061291
Location (UCSC) Chr 18:
67.96 – 68 Mb
Chr 18:
88.67 – 88.93 Mb
PubMed search [1] [2]

Suppressor of cytokine signaling 6 is a protein that in humans is encoded by the SOCS6 gene.[1][2][3]

The protein encoded by this gene contains a SH2 domain and a CIS homolog domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by GM-CSF and EPO in hematopoietic cells. A high expression level of this gene was found in factor-independent chronic myelogenous leukemia (CML) and erythroleukemia (HEL) cell lines.[3]


  1. ^ Masuhara M, Sakamoto H, Matsumoto A, Suzuki R, Yasukawa H, Mitsui K, Wakioka T, Tanimura S, Sasaki A, Misawa H, Yokouchi M, Ohtsubo M, Yoshimura A (Nov 1997). "Cloning and characterization of novel CIS family genes". Biochem Biophys Res Commun 239 (2): 439–46. doi:10.1006/bbrc.1997.7484. PMID 9344848. 
  2. ^ Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (Nov 2000). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152. 
  3. ^ a b "Entrez Gene: SOCS6 suppressor of cytokine signaling 6". 

Further reading[edit]