SOX1 (for Sex determining region Y-box 1) is a transcription factor in the Sox protein family. SOX1 expression is restricted to neuroectoderm in the tetrapod embryo. [1 ] SOX1 is involved in early [2 ] central nervous system development, where it is functionally redundant with SOX3 and to a lesser degree SOX2, and maintenance of neural progenitor cell identity. SOX1 is expressed particularly in the ventral striatum, and Sox1-deficient mice have altered striatum development, leading e.g. to epilepsy. [1 ]
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References [ edit ]
^ a b Guth SI, Wegner M (October 2008). "Having it both ways: Sox protein function between conservation and innovation". Cell. Mol. Life Sci. 65 (19): 3000–18. doi: 10.1007/s00018-008-8138-7. PMID 18516494.
^ Nitta KR, Takahashi S, Haramoto Y, Fukuda M, Onuma Y, Asashima M (December 2006). "Expression of Sox1 during Xenopus early embryogenesis". Biochem. Biophys. Res. Commun. 351 (1): 287–93. doi: 10.1016/j.bbrc.2006.10.040. PMID 17056008.
β-Scaffold factors with minor groove contacts
(0) Other transcription factors
transcription factor/coregulator deficiencies B bsyn: dna ( repl, cycl, reco, repr) · tscr ( fact, tcrg, nucl, rnat, rept, ptts) · tltn ( risu, pttl, nexn) · dnab, rnab/ runp · stru ( domn, 1°, 2°, 3°, 4°)