SOX21

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SRY (sex determining region Y)-box 21
Identifiers
Symbols SOX21 ; SOX25
External IDs OMIM604974 MGI2654070 HomoloGene5143 GeneCards: SOX21 Gene
RNA expression pattern
PBB GE SOX21 208468 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 11166 223227
Ensembl ENSG00000125285 ENSMUSG00000061517
UniProt Q9Y651 Q811W0
RefSeq (mRNA) NM_007084 NM_177753
RefSeq (protein) NP_009015 NP_808421
Location (UCSC) Chr 13:
95.36 – 95.36 Mb
Chr 14:
118.23 – 118.24 Mb
PubMed search [1] [2]

Transcription factor SOX-21 is a protein that in humans is encoded by the SOX21 gene.[1][2] It is a member of the Sox gene family of transcription factors.

Function[edit]

In the chick embryo, Sox21 promotes neuronal cellular differentiation by counteracting the activity of Sox1, Sox2, and Sox3, which maintain neural cells in an undifferentiated state.[3]

SOX21 knockout mice display hair loss beginning from postnatal day 11. New hair regrowth was initiated a few days later but was followed by renewed hair loss. Sox21 is also expressed in the hair shaft cuticle in humans and consequently variants of the Sox21 gene could be responsible for some hair loss conditions in humans.[4]

See also[edit]

References[edit]

  1. ^ Malas S, Duthie S, Deloukas P, Episkopou V (Sep 1999). "The isolation and high-resolution chromosomal mapping of human SOX14 and SOX21; two members of the SOX gene family related to SOX1, SOX2, and SOX3". Mamm Genome 10 (9): 934–7. doi:10.1007/s003359901118. PMID 10441749. 
  2. ^ "Entrez Gene: SOX21 SRY (sex determining region Y)-box 21". 
  3. ^ Sandberg M, Källström M, Muhr J (August 2005). "Sox21 promotes the progression of vertebrate neurogenesis". Nat. Neurosci. 8 (8): 995–1001. doi:10.1038/nn1493. PMID 15995704. 
  4. ^ Kiso M, Tanaka S, Saba R, Matsuda S, Shimizu A, Ohyama M, Okano HJ, Shiroishi T, Okano H, Saga Y (June 2009). "The disruption of Sox21-mediated hair shaft cuticle differentiation causes cyclic alopecia in mice". Proc. Natl. Acad. Sci. U.S.A. 106 (23): 9292–7. doi:10.1073/pnas.0808324106. PMC 2695080. PMID 19470461. Lay summaryReuters UK. 

Further reading[edit]