SOX5

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SRY (sex determining region Y)-box 5
Protein SOX5 PDB 1i11.png
PDB rendering based on 1i11.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols SOX5 ; L-SOX5; L-SOX5B; L-SOX5F
External IDs OMIM604975 MGI98367 HomoloGene21378 GeneCards: SOX5 Gene
RNA expression pattern
PBB GE SOX5 207336 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 6660 20678
Ensembl ENSG00000134532 ENSMUSG00000041540
UniProt P35711 P35710
RefSeq (mRNA) NM_001261414 NM_001113559
RefSeq (protein) NP_001248343 NP_001107031
Location (UCSC) Chr 12:
23.68 – 24.1 Mb
Chr 6:
143.83 – 144.78 Mb
PubMed search [1] [2]

Transcription factor SOX-5 is a protein that in humans is encoded by the SOX5 gene.[1][2]

This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. The encoded protein may play a role in chondrogenesis. A pseudogene of this gene is located on chromosome 8. Multiple transcript variants encoding distinct isoforms have been identified for this gene.[2]

See also[edit]

References[edit]

  1. ^ Wunderle VM, Critcher R, Ashworth A, Goodfellow PN (Jan 1997). "Cloning and characterization of SOX5, a new member of the human SOX gene family". Genomics 36 (2): 354–8. doi:10.1006/geno.1996.0474. PMID 8812465. 
  2. ^ a b "Entrez Gene: SOX5 SRY (sex determining region Y)-box 5". 

Further reading[edit]