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SAM pointed domain containing ETS transcription factor
Protein SPDEF PDB 1yo5.png
PDB rendering based on 1yo5.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols SPDEF ; PDEF; bA375E1.3
External IDs OMIM608144 MGI1353422 HomoloGene8231 GeneCards: SPDEF Gene
RNA expression pattern
PBB GE SPDEF 213441 x at tn.png
PBB GE SPDEF 214404 x at tn.png
PBB GE SPDEF 220192 x at tn.png
More reference expression data
Species Human Mouse
Entrez 25803 30051
Ensembl ENSG00000124664 ENSMUSG00000024215
UniProt O95238 Q9WTP3
RefSeq (mRNA) NM_001252294 NM_013891
RefSeq (protein) NP_001239223 NP_038919
Location (UCSC) Chr 6:
34.51 – 34.52 Mb
Chr 17:
27.71 – 27.73 Mb
PubMed search [1] [2]

SAM pointed domain-containing Ets transcription factor is a protein that in humans is encoded by the SPDEF gene.[1][2][3]

PDEF is an ETS transcription factor expressed in prostate epithelial cells. It acts as an androgen-independent transactivator of PSA (MIM 176820) expression.[supplied by OMIM][3]


SPDEF has been shown to interact with NKX3-1.[4]

The Protein Kinase CK2 has been shown to control the stability of PDEF. [5]


  1. ^ Oettgen P, Finger E, Sun Z, Akbarali Y, Thamrongsak U, Boltax J, Grall F, Dube A, Weiss A, Brown L, Quinn G, Kas K, Endress G, Kunsch C, Libermann TA (February 2000). "PDEF, a novel prostate epithelium-specific ets transcription factor, interacts with the androgen receptor and activates prostate-specific antigen gene expression". J Biol Chem 275 (2): 1216–25. doi:10.1074/jbc.275.2.1216. PMID 10625666. 
  2. ^ Johannessen JV, Finseth I (July 1983). "Electron micrographs in five minutes". Ultrastruct Pathol 4 (1): 97–100. doi:10.3109/01913128309140576. PMID 6857767. 
  3. ^ a b "Entrez Gene: SPDEF SAM pointed domain containing ets transcription factor". 
  4. ^ Chen, Hui; Nandi Asit K; Li Xiang; Bieberich Charles J (January 2002). "NKX-3.1 interacts with prostate-derived Ets factor and regulates the activity of the PSA promoter". Cancer Res. (United States) 62 (2): 338–40. ISSN 0008-5472. PMID 11809674. 
  5. ^ Chisholm, Christine; Padmanabhan Achuth; Guan Bin; Li Xiang; Kalra Simran; Bieberich Charles J (2010). "Protein Kinase CK2 regulates the stability of prostate derived Ets factor". The Open Cancer Journal (Bentham Science) 3: 109–115. doi:10.2174/1874079001003010109. http://www.benthamscience.com/open/tocj/articles/V003/SI0022TOCJ/109TOCJ.pdf

Further reading[edit]