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SPSA can refer to:
- Scottish Police Services Authority, a public body of the Scottish Government responsible for certain central services for police forces
- Southeastern Public Service Authority, the solid waste management agency for the one-million-population region south of Hampton Roads Harbor and the lower James River in Virginia, United States
- Simultaneous perturbation stochastic approximation, a stochastic method for optimization, especially appropriate for multivariable problems
- SPSA: Sindh Punjabi Student Association
- SPSA: Somerset Prostate Support Association, a UK charity providing support to men who have prostate problems including prostate cancer and support to their families
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