SRA1

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Steroid receptor RNA activator 1
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols SRA1 ; SRA; SRAP; STRAA1; pp7684
External IDs OMIM603819 MGI1344414 HomoloGene11906 GeneCards: SRA1 Gene
RNA expression pattern
PBB GE SRA1 gnf1h06172 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 10011 24068
Ensembl ENSG00000213523 ENSMUSG00000006050
UniProt Q9HD15 Q80VJ2
RefSeq (mRNA) NM_001035235 NM_001164406
RefSeq (protein) NP_001030312 NP_001157878
Location (UCSC) Chr 5:
139.92 – 139.94 Mb
Chr 18:
36.67 – 36.67 Mb
PubMed search [1] [2]

Steroid receptor RNA activator 1 also known as steroid receptor RNA activator protein (SRAP) is a protein that in humans is encoded by the SRA1 gene.[1][2] The mRNA transcribed from the SRA1 gene is a component of the ribonucleoprotein complex containing NCOA1. This functional RNA also encodes a protein.[3]

Function[edit]

This gene is involved in transcriptional coactivation by steroid receptor. There is currently data suggesting this gene encodes both a non-coding RNA that functions as part of a ribonucleoprotein complex and a protein coding mRNA. Increased expression of both the transcript and the protein is associated with cancer.[2]

Interactions[edit]

SRA1 has been shown to interact with:

The SRAP has been shown to interact with its SRA RNA counterpart via its RRM-like domain interacting with the functional sub-structure STR7 of SRA RNA.[6]

References[edit]

  1. ^ Lanz RB, McKenna NJ, Onate SA, Albrecht U, Wong J, Tsai SY, Tsai MJ, O'Malley BW (Apr 1999). "A steroid receptor coactivator, SRA, functions as an RNA and is present in an SRC-1 complex". Cell 97 (1): 17–27. doi:10.1016/S0092-8674(00)80711-4. PMID 10199399. 
  2. ^ a b "Entrez Gene: SRA1 steroid receptor RNA activator 1". 
  3. ^ Chooniedass-Kothari S, Emberley E, Hamedani MK, Troup S, Wang X, Czosnek A, Hube F, Mutawe M, Watson PH, Leygue E (May 2004). "The steroid receptor RNA activator is the first functional RNA encoding a protein". FEBS Lett. 566 (1–3): 43–7. doi:10.1016/j.febslet.2004.03.104. PMID 15147866. 
  4. ^ a b c Watanabe M, Yanagisawa J, Kitagawa H, Takeyama K, Ogawa S, Arao Y, Suzawa M, Kobayashi Y, Yano T, Yoshikawa H, Masuhiro Y, Kato S (March 2001). "A subfamily of RNA-binding DEAD-box proteins acts as an estrogen receptor alpha coactivator through the N-terminal activation domain (AF-1) with an RNA coactivator, SRA". EMBO J. 20 (6): 1341–52. doi:10.1093/emboj/20.6.1341. PMC 145523. PMID 11250900. 
  5. ^ Shi Y, Downes M, Xie W, Kao HY, Ordentlich P, Tsai CC, Hon M, Evans RM (May 2001). "Sharp, an inducible cofactor that integrates nuclear receptor repression and activation". Genes Dev. 15 (9): 1140–51. doi:10.1101/gad.871201. PMC 312688. PMID 11331609. 
  6. ^ Hubé F, Velasco G, Rollin J, Furling D, Francastel C (Sep 2010). "Steroid receptor RNA activator protein binds to and counteracts SRA RNA-mediated activation of MyoD and muscle differentiation". Nucleic Acids Res. 39 (2): 513–25. doi:10.1093/nar/gkq833. PMC 3025577. PMID 20855289. 


Further reading[edit]

External links[edit]