From Wikipedia, the free encyclopedia
Jump to: navigation, search
Steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2)
Symbols SRD5A2 ; MGC138457
External IDs OMIM607306 MGI2150380 HomoloGene37292 ChEMBL: 1856 GeneCards: SRD5A2 Gene
EC number
RNA expression pattern
PBB GE SRD5A2 206938 at tn.png
More reference expression data
Species Human Mouse
Entrez 6716 94224
Ensembl ENSG00000049319 ENSMUSG00000038541
UniProt P31213 Q99N99
RefSeq (mRNA) NM_000348 NM_053188
RefSeq (protein) NP_000339 NP_444418
Location (UCSC) Chr 2:
31.6 – 31.66 Mb
Chr 17:
74.02 – 74.05 Mb
PubMed search [1] [2]

3-oxo-5-alpha-steroid 4-dehydrogenase 2 is an enzyme that in humans is encoded by the SRD5A2 gene.[1][2]

Steroid 5-alpha reductase catalyzes the conversion of the male sex hormone testosterone into the more potent androgen, dihydrotestosterone.

This gene encodes a microsomal protein expressed at high levels in androgen-sensitive tissues such as the prostate. The encoded protein is active at acidic pH and is sensitive to the 4-azasteroid inhibitor finasteride. Deficiencies in this gene can result in male pseudohermaphroditism, specifically pseudovaginal perineoscrotal hypospadias (PPSH).[2]

See also[edit]


  1. ^ Thigpen AE, Davis DL, Milatovich A, Mendonca BB, Imperato-McGinley J, Griffin JE, Francke U, Wilson JD, Russell DW (Oct 1992). "Molecular genetics of steroid 5 alpha-reductase 2 deficiency". J Clin Invest 90 (3): 799–809. doi:10.1172/JCI115954. PMC 329933. PMID 1522235. 
  2. ^ a b "Entrez Gene: SRD5A2 steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2)". 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.