SREBF1

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Sterol regulatory element binding transcription factor 1
Protein SREBF1 PDB 1am9.png
PDB rendering based on 1am9.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols SREBF1 ; SREBP-1c; SREBP1; bHLHd1
External IDs OMIM184756 MGI107606 HomoloGene3079 GeneCards: SREBF1 Gene
RNA expression pattern
PBB GE SREBF1 202308 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 6720 20787
Ensembl ENSG00000072310 ENSMUSG00000020538
UniProt P36956 Q9WTN3
RefSeq (mRNA) NM_001005291 NM_011480
RefSeq (protein) NP_001005291 NP_035610
Location (UCSC) Chr 17:
17.71 – 17.74 Mb
Chr 11:
60.2 – 60.22 Mb
PubMed search [1] [2]

Sterol regulatory element-binding transcription factor 1 (SREBF1) also known as sterol regulatory element-binding protein 1 (SREBP-1) is a protein that in humans is encoded by the SREBF1 gene.[1][2]

This gene is located within the Smith-Magenis syndrome region on chromosome 17. Two transcript variants encoding different isoforms have been found for this gene.[3] The isoforms are SREBP-1a and -1c (ADD-1).

Function[edit]

The proteins encoded by this gene are transcription factors that bind to a sequence in the promoter of different genes, called sterol regulatory element-1 (SRE1). This element is a decamer flanking the LDL receptor gene and other genes involved in, for instance, sterol biosynthesis. The protein is synthesized as a precursor that is attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription by binding to the SRE1. Sterols inhibit the cleavage of the precursor, and the mature nuclear form is rapidly catabolized, thereby reducing transcription. The protein is a member of the basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor family.

SREBP-1c regulates genes required for glucose metabolism and fatty acid and lipid production and its expression is regulated by insulin.[4] SREBP-1a regulates genes related to lipid and cholesterol production and its activity is regulated by sterol levels in the cell.[5]

Interactions[edit]

SREBF1 has been shown to interact with TWIST2,[6] CREB-binding protein,[7] DAX1[8] and LMNA.[9]

See also[edit]

References[edit]

  1. ^ Yokoyama C, Wang X, Briggs MR, Admon A, Wu J, Hua X, Goldstein JL, Brown MS (November 1993). "SREBP-1, a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene". Cell 75 (1): 187–97. doi:10.1016/S0092-8674(05)80095-9. PMID 8402897. 
  2. ^ Hua X, Wu J, Goldstein JL, Brown MS, Hobbs HH (June 1995). "Structure of the human gene encoding sterol regulatory element binding protein-1 (SREBF1) and localization of SREBF1 and SREBF2 to chromosomes 17p11.2 and 22q13". Genomics 25 (3): 667–673. doi:10.1016/0888-7543(95)80009-B. PMID 7759101. 
  3. ^ "Entrez Gene: SREBF1 sterol regulatory element binding transcription factor 1". 
  4. ^ Ferré P, Foufelle F (October 2010). "Hepatic steatosis: a role for de novo lipogenesis and the transcription factor SREBP-1c". Diabetes Obes Metab 12 (Suppl 2): 83–92. doi:10.1111/j.1463-1326.2010.01275.x. PMID 21029304. 
  5. ^ Eberlé D, Hegarty B, Bossard P, Ferré P, Foufelle F (November 2004). "SREBP transcription factors: master regulators of lipid homeostasis". Biochimie 86 (11): 839–48. doi:10.1016/j.biochi.2004.09.018. PMID 15589694. 
  6. ^ Lee, Yun Sok; Lee Hyoung Ho, Park Jiyoung, Yoo Eung Jae, Glackin Carlotta A, Choi Young Il, Jeon Sung Ho, Seong Rho Hyun, Park Sang Dai, Kim Jae Bum (Dec 2003). "Twist2, a novel ADD1/SREBP1c interacting protein, represses the transcriptional activity of ADD1/SREBP1c". Nucleic Acids Res. (England) 31 (24): 7165–7174. doi:10.1093/nar/gkg934. PMC 291873. PMID 14654692. 
  7. ^ Oliner, J D; Andresen J M, Hansen S K, Zhou S, Tjian R (November 1996). "SREBP transcriptional activity is mediated through an interaction with the CREB-binding protein". Genes Dev. (UNITED STATES) 10 (22): 2903–2911. doi:10.1101/gad.10.22.2903. ISSN 0890-9369. PMID 8918891. 
  8. ^ Lopez, D; Shea-Eaton W, Sanchez M D, McLean M P (Dec 2001). "DAX-1 represses the high-density lipoprotein receptor through interaction with positive regulators sterol regulatory element-binding protein-1a and steroidogenic factor-1". Endocrinology (United States) 142 (12): 5097–5106. doi:10.1210/en.142.12.5097. ISSN 0013-7227. PMID 11713202. 
  9. ^ Lloyd, David J; Trembath Richard C, Shackleton Sue (April 2002). "A novel interaction between lamin A and SREBP1: implications for partial lipodystrophy and other laminopathies". Hum. Mol. Genet. (England) 11 (7): 769–777. doi:10.1093/hmg/11.7.769. ISSN 0964-6906. PMID 11929849. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.