SRI (gene)

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Protein SRI PDB 1gjy.png
PDB rendering based on 1gjy.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols SRI ; CP-22; CP22; SCN; V19
External IDs OMIM182520 MGI98419 HomoloGene37736 GeneCards: SRI Gene
RNA expression pattern
PBB GE SRI 208921 s at tn.png
PBB GE SRI 208920 at tn.png
More reference expression data
Species Human Mouse
Entrez 6717 109552
Ensembl ENSG00000075142 ENSMUSG00000003161
UniProt P30626 Q6P069
RefSeq (mRNA) NM_001256891 NM_001080974
RefSeq (protein) NP_001243820 NP_001074443
Location (UCSC) Chr 7:
87.83 – 87.86 Mb
Chr 5:
8.05 – 8.07 Mb
PubMed search [1] [2]

Sorcin is a protein that in humans is encoded by the SRI gene.[1][2]


SRI (gene) has been shown to interact with Ryanodine receptor 2,[3] ANXA7[4] and GCA.[5]


  1. ^ Van der Bliek AM, Baas F, Van der Velde-Koerts T, Biedler JL, Meyers MB, Ozols RF, Hamilton TC, Joenje H, Borst P (Nov 1988). "Genes amplified and overexpressed in human multidrug-resistant cell lines". Cancer Res 48 (21): 5927–32. PMID 2901906. 
  2. ^ "Entrez Gene: SRI sorcin". 
  3. ^ Meyers, M B; Pickel V M; Sheu S S; Sharma V K; Scotto K W; Fishman G I (Nov 1995). "Association of sorcin with the cardiac ryanodine receptor". J. Biol. Chem. (UNITED STATES) 270 (44): 26411–8. doi:10.1074/jbc.270.44.26411. ISSN 0021-9258. PMID 7592856. 
  4. ^ Brownawell, A M; Creutz C E (Aug 1997). "Calcium-dependent binding of sorcin to the N-terminal domain of synexin (annexin VII)". J. Biol. Chem. (UNITED STATES) 272 (35): 22182–90. doi:10.1074/jbc.272.35.22182. ISSN 0021-9258. PMID 9268363. 
  5. ^ Hansen, Christian; Tarabykina Svetlana; la Cour Jonas M; Lollike Karsten; Berchtold Martin W (Jun 2003). "The PEF family proteins sorcin and grancalcin interact in vivo and in vitro". FEBS Lett. (Netherlands) 545 (2–3): 151–4. doi:10.1016/S0014-5793(03)00518-0. ISSN 0014-5793. PMID 12804766. 

Further reading[edit]