Serine/threonine-protein kinase SRPK1 is an enzyme that in humans is encoded by the SRPK1gene.
This gene encodes a serine/arginine protein kinase specific for the SR (serine/arginine-rich domain) family of splicing factors. The protein localizes to the nucleus and the cytoplasm. It is thought to play a role in regulation of both constitutive and alternative splicing by regulating intracellular localization of splicing factors. A second alternatively spliced transcript variant for this gene has been described, but its full length nature has not been determined.
Some cancers are VEGF dependant (for angiogenesis). SRPK1 activates (phosphorylates) VEGF splicing factor. SRPK1 inhibitors (eg 'SPHINX compounds' ) are being investigated as treatments for prostate cancer.
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