SRPK1

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SRSF protein kinase 1
Protein SRPK1 PDB 1wak.png
PDB rendering based on 1wak.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols SRPK1 ; SFRSK1
External IDs OMIM601939 MGI106908 HomoloGene110962 ChEMBL: 4375 GeneCards: SRPK1 Gene
EC number 2.7.11.1
RNA expression pattern
PBB GE SRPK1 202199 s at tn.png
PBB GE SRPK1 202200 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 6732 20815
Ensembl ENSG00000096063 ENSMUSG00000004865
UniProt Q96SB4 O70551
RefSeq (mRNA) NM_003137 NM_016795
RefSeq (protein) NP_003128 NP_058075
Location (UCSC) Chr 6:
35.8 – 35.89 Mb
Chr 17:
28.59 – 28.62 Mb
PubMed search [1] [2]

Serine/threonine-protein kinase SRPK1 is an enzyme that in humans is encoded by the SRPK1 gene.[1][2][3]

This gene encodes a serine/arginine protein kinase specific for the SR (serine/arginine-rich domain) family of splicing factors. The protein localizes to the nucleus and the cytoplasm. It is thought to play a role in regulation of both constitutive and alternative splicing by regulating intracellular localization of splicing factors. A second alternatively spliced transcript variant for this gene has been described, but its full length nature has not been determined.[3]

Possible anti-cancer target[edit]

Some cancers are VEGF dependant (for angiogenesis). SRPK1 activates (phosphorylates) VEGF splicing factor. SRPK1 inhibitors (eg 'SPHINX compounds' [4]) are being investigated as treatments for prostate cancer.[5][6]

Interactions[edit]

SRPK1 has been shown to interact with SNRP70[7][8] and ASF/SF2.[7][9][10][11]

References[edit]

  1. ^ Gui JF, Lane WS, Fu XD (Jul 1994). "A serine kinase regulates intracellular localization of splicing factors in the cell cycle". Nature 369 (6482): 678–82. doi:10.1038/369678a0. PMID 8208298. 
  2. ^ Wang HY, Arden KC, Bermingham JR Jr, Viars CS, Lin W, Boyer AD, Fu XD (May 1999). "Localization of serine kinases, SRPK1 (SFRSK1) and SRPK2 (SFRSK2), specific for the SR family of splicing factors in mouse and human chromosomes". Genomics 57 (2): 310–5. doi:10.1006/geno.1999.5770. PMID 10198174. 
  3. ^ a b "Entrez Gene: SRPK1 SFRS protein kinase 1". 
  4. ^ Development of novel anti-angiogenic SRPK1 inhibitors
  5. ^ Molecular breakthrough could halt spread of prostate cancer
  6. ^ "Serine-arginine protein kinase 1 (SRPK1) inhibition as a potential novel targeted therapeutic strategy in prostate cancer.". 2014. 
  7. ^ a b Wang, H Y; Lin W; Dyck J A; Yeakley J M; Songyang Z; Cantley L C; Fu X D (Feb 1998). "SRPK2: A Differentially Expressed SR Protein-specific Kinase Involved in Mediating the Interaction and Localization of Pre-mRNA Splicing Factors in Mammalian Cells". J. Cell Biol. (UNITED STATES) 140 (4): 737–50. doi:10.1083/jcb.140.4.737. ISSN 0021-9525. PMC 2141757. PMID 9472028. 
  8. ^ Kamachi, Makoto; Le Truc M; Kim Susan J; Geiger Meghan E; Anderson Paul; Utz Paul J (Nov 2002). "Human Autoimmune Sera as Molecular Probes for the Identification of an Autoantigen Kinase Signaling Pathway". J. Exp. Med. (United States) 196 (9): 1213–25. doi:10.1084/jem.20021167. ISSN 0022-1007. PMC 2194102. PMID 12417631. 
  9. ^ Lukasiewicz, Randall; Velazquez-Dones Adolfo, Huynh Nhat, Hagopian Jonathan, Fu Xiang-Dong, Adams Joseph, Ghosh Gourisankar (Aug 2007). "Structurally unique yeast and mammalian serine-arginine protein kinases catalyze evolutionarily conserved phosphorylation reactions". J. Biol. Chem. (United States) 282 (32): 23036–43. doi:10.1074/jbc.M611305200. ISSN 0021-9258. PMID 17517895. 
  10. ^ Umehara, Hiroshi; Nishii Yoichi; Morishima Masaki; Kakehi Yoshiyuki; Kioka Noriyuki; Amachi Teruo; Koizumi Jun; Hagiwara Masatoshi; Ueda Kazumitsu (Feb 2003). "Effect of cisplatin treatment on speckled distribution of a serine/arginine-rich nuclear protein CROP/Luc7A". Biochem. Biophys. Res. Commun. (United States) 301 (2): 324–9. doi:10.1016/S0006-291X(02)03017-6. ISSN 0006-291X. PMID 12565863. 
  11. ^ Koizumi, J; Okamoto Y; Onogi H; Mayeda A; Krainer A R; Hagiwara M (Apr 1999). "The subcellular localization of SF2/ASF is regulated by direct interaction with SR protein kinases (SRPKs)". J. Biol. Chem. (UNITED STATES) 274 (16): 11125–31. doi:10.1074/jbc.274.16.11125. ISSN 0021-9258. PMID 10196197. 

Further reading[edit]