SSBP1

Single-stranded DNA binding protein 1
PDB rendering based on 1s3o.
Available structures PDB 1S3O, 2DUD, 3ULL
Identifiers
Symbols	SSBP1; Mt-SSB; SOSS-B1; SSBP; mtSSB
External IDs	OMIM: 600439 MGI: 1920040 HomoloGene: 74462 GeneCards: SSBP1 Gene
Gene Ontology Molecular function • DNA binding • single-stranded DNA binding Cellular component • mitochondrion • mitochondrial nucleoid Biological process • DNA replication • positive regulation of helicase activity • mitochondrion morphogenesis Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6742	381760
Ensembl	ENSG00000106028	ENSMUSG00000029911
UniProt	Q04837	Q8R2K3
RefSeq (mRNA)	NM_003143	NM_028358
RefSeq (protein)	NP_003134	NP_082634
Location (UCSC)	Chr 7: 141.44 – 141.49 Mb	Chr 6: 40.42 – 40.43 Mb
PubMed search	[1]	[2]

Single-stranded DNA-binding protein, mitochondrial is a protein that in humans is encoded by the SSBP1 gene.

SSBP is a housekeeping gene involved in mitochondrial biogenesis (Tiranti et al., 1995).[supplied by OMIM]

Further reading

• Tiranti V, Rocchi M, DiDonato S, Zeviani M (1993). "Cloning of human and rat cDNAs encoding the mitochondrial single-stranded DNA-binding protein (SSB)". Gene 126 (2): 219–225. doi:10.1016/0378-1119(93)90370-I. PMID 8482537. 
• Yang C, Curth U, Urbanke C, Kang C (1997). "Crystal structure of human mitochondrial single-stranded DNA binding protein at 2.4 A resolution". Nat. Struct. Biol. 4 (2): 153–157. doi:10.1038/nsb0297-153. PMID 9033597. 
• Schultz RA, Swoap SJ, McDaniel LD et al (1998). "Differential expression of mitochondrial DNA replication factors in mammalian tissues". J. Biol. Chem. 273 (6): 3447–3451. doi:10.1074/jbc.273.6.3447. PMID 9452467. 
• Spelbrink JN, Toivonen JM, Hakkaart GA et al (2000). "In vivo functional analysis of the human mitochondrial DNA polymerase POLG expressed in cultured human cells". J. Biol. Chem. 275 (32): 24818–24828. doi:10.1074/jbc.M000559200. PMID 10827171. 
• Müller-Höcker J, Schäfer S, Li K (2002). "Immunocytochemical localization of mitochondrial single-stranded DNA-binding protein in mitochondria-rich cells of normal and neoplastic human tissue". Appl. Immunohistochem. Mol. Morphol. 9 (3): 276–280. doi:10.1097/00022744-200109000-00013. PMID 11556757. 
• Takamatsu C, Umeda S, Ohsato T et al (2002). "Regulation of mitochondrial D-loops by transcription factor A and single-stranded DNA-binding protein". EMBO Rep. 3 (5): 451–456. doi:10.1093/embo-reports/kvf099. PMC 1084112. PMID 11964388. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1084112. 
• Chen L, Segal D, Hukriede NA et al (2002). "Ssdp proteins interact with the LIM-domain-binding protein Ldb1 to regulate development". Proc. Natl. Acad. Sci. U.S.A. 99 (22): 14320–14325. doi:10.1073/pnas.212532399. PMC 137882. PMID 12381786. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=137882. 
• Diez-Tascón C, Dodds KG, Crawford AM (2003). "Linkage mapping of the ovine single-stranded DNA-binding protein 1 (SSBP1) using microsatellite marker OARCDT7". Anim. Genet. 33 (6): 468–468. doi:10.1046/j.1365-2052.2002.00938_1.x. PMID 12464025. 
• Strausberg RL, Feingold EA, Grouse LH et al (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Bayarsaihan D (2003). "SSDP1 gene encodes a protein with a conserved N-terminal FORWARD domain". Biochim. Biophys. Acta 1599 (1–2): 152–5. PMID 12479417. 
• Scherer SW, Cheung J, MacDonald JR et al (2003). "Human chromosome 7: DNA sequence and biology". Science 300 (5620): 767–772. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2882961. 
• Hillier LW, Fulton RS, Fulton LA et al (2003). "The DNA sequence of human chromosome 7". Nature 424 (6945): 157–164. doi:10.1038/nature01782. PMID 12853948. 
• Gerhard DS, Wagner L, Feingold EA et al (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Pocernich CB, Poon HF, Boyd-Kimball D et al (2005). "Proteomic analysis of oxidatively modified proteins induced by the mitochondrial toxin 3-nitropropionic acid in human astrocytes expressing the HIV protein tat". Brain Res. Mol. Brain Res. 133 (2): 299–306. doi:10.1016/j.molbrainres.2004.10.024. PMID 15710247.