SSR1

Signal sequence receptor, alpha
Identifiers
Symbols	SSR1; DKFZp781N23103; FLJ14232; FLJ22100; FLJ23034; FLJ78242; FLJ93042; TRAPA
External IDs	OMIM: 600868 MGI: 105082 HomoloGene: 2368 GeneCards: SSR1 Gene
Gene Ontology Molecular function • signal sequence binding Cellular component • endoplasmic reticulum • endoplasmic reticulum membrane • membrane • integral to membrane Biological process • cotranslational protein targeting to membrane • positive regulation of cell proliferation Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6745	107513
Ensembl	ENSG00000124783	ENSMUSG00000021427
UniProt	P43307	n/a
RefSeq (mRNA)	NM_003144	NM_025965.3
RefSeq (protein)	NP_003135	NP_080241.3
Location (UCSC)	Chr 6: 7.27 – 7.35 Mb	Chr 13: 38.06 – 38.09 Mb
PubMed search	[1]	[2]

Translocon-associated protein subunit alpha is a protein that in humans is encoded by the SSR1 gene.

The signal sequence receptor (SSR) is a glycosylated endoplasmic reticulum (ER) membrane receptor associated with protein translocation across the ER membrane. The SSR consists of 2 subunits, a 34-kD glycoprotein encoded by this gene and a 22-kD glycoprotein. This gene generates several mRNA species as a result of complex alternative polyadenylation. This gene is unusual in that it utilizes arrays of polyA signal sequences that are exclusively non-canonical.

Further reading

• Wei ML, Cresswell P (1992). "HLA-A2 molecules in an antigen-processing mutant cell contain signal sequence-derived peptides.". Nature 356 (6368): 443–6. doi:10.1038/356443a0. PMID 1557127. 
• Vogel F, Hartmann E, Görlich D, Rapoport TA (1991). "Segregation of the signal sequence receptor protein in the rough endoplasmic reticulum membrane.". Eur. J. Cell Biol. 53 (2): 197–202. PMID 1964414. 
• Hartmann E, Görlich D, Kostka S, et al. (1993). "A tetrameric complex of membrane proteins in the endoplasmic reticulum.". Eur. J. Biochem. 214 (2): 375–81. doi:10.1111/j.1432-1033.1993.tb17933.x. PMID 7916687. 
• Hartmann E, Prehn S (1994). "The N-terminal region of the alpha-subunit of the TRAP complex has a conserved cluster of negative charges.". FEBS Lett. 349 (3): 324–6. doi:10.1016/0014-5793(94)00693-8. PMID 8050590. 
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
• Hu T, Guan T, Gerace L (1996). "Molecular and functional characterization of the p62 complex, an assembly of nuclear pore complex glycoproteins". J. Cell Biol. 134 (3): 589–601. doi:10.1083/jcb.134.3.589. PMC 2120945. PMID 8707840. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2120945. 
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
• Hirama T, Miller CW, Koeffler HP (1999). "Translocon-associated protein alpha transcripts are induced by granulocyte-macrophage colony-stimulating factor and exhibit complex alternative polyadenylation". FEBS Lett. 455 (3): 223–7. doi:10.1016/S0014-5793(99)00885-6. PMID 10437777. 
• Wang L, Dobberstein B (1999). "Oligomeric complexes involved in translocation of proteins across the membrane of the endoplasmic reticulum". FEBS Lett. 457 (3): 316–22. doi:10.1016/S0014-5793(99)01075-3. PMID 10471800. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Zhang H, Li XJ, Martin DB, Aebersold R (2003). "Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry". Nat. Biotechnol. 21 (6): 660–6. doi:10.1038/nbt827. PMID 12754519. 
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070. 
• Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743. 
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.