SSX1

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Synovial sarcoma, X breakpoint 1
Identifiers
Symbols SSX1 ; CT5.1; SSRC
External IDs OMIM312820 HomoloGene136735 GeneCards: SSX1 Gene
RNA expression pattern
PBB GE SSX1 206627 s at tn.png
PBB GE SSX1 206626 x at tn.png
PBB GE SSX1 210394 x at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 6756 387132
Ensembl ENSG00000126752 ENSMUSG00000023165
UniProt Q16384 Q80ZT4
RefSeq (mRNA) NM_001278691 NM_001001450
RefSeq (protein) NP_001265620 NP_001001450
Location (UCSC) Chr HG1436_HG1432_PATCH:
48.11 – 48.13 Mb
Chr X:
8.45 – 8.46 Mb
PubMed search [1] [2]

Protein SSX1 is a protein that in humans is encoded by the SSX1 gene.[1][2]

The product of this gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneously humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. SSX1, SSX2 and SSX4 genes have been involved in the t(X;18) translocation characteristically found in all synovial sarcomas. This translocation results in the fusion of the synovial sarcoma translocation gene on chromosome 18 to one of the SSX genes on chromosome X. The encoded hybrid proteins are probably responsible for transforming activity.[2]

References[edit]

  1. ^ de Leeuw B, Balemans M, Olde Weghuis D, Geurts van Kessel A (Oct 1995). "Identification of two alternative fusion genes, SYT-SSX1 and SYT-SSX2, in t(X;18)(p11.2;q11.2)-positive synovial sarcomas". Hum Mol Genet 4 (6): 1097–9. doi:10.1093/hmg/4.6.1097. PMID 7655467. 
  2. ^ a b "Entrez Gene: SSX1 synovial sarcoma, X breakpoint 1". 

Further reading[edit]