ST-1936

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ST-1936
ST-1936 structure.png
Systematic (IUPAC) name
2-(2-methyl-5-chloro-1H-indol-3-yl)-N,N-dimethylethanamine
Clinical data
Legal status
?
Identifiers
CAS number 1210-81-7 YesY
ATC code None
PubChem CID 9921064
Chemical data
Formula C13H17ClN2 
Mol. mass 236.74 g/mol

ST-1936 (2-Methyl-5-chloro-N,N-dimethyltryptamine) is a tryptamine derivative which is used in scientific research. It acts as a selective 5-HT6 receptor agonist, with a Ki of 13 nM, and much weaker action at 5-HT2B and 5-HT7 subtypes. In animal studies it has been found to increase dopamine and noradrenaline mediated signalling but decreases glutamatergic transmission, and has antidepressant effects.[1][2][3][4]

See also[edit]

References[edit]

  1. ^ Valentini, V.; Frau, R.; Bordi, F.; Borsini, F.; Di Chiara, G. (2011). "A microdialysis study of ST1936, a novel 5-HT6 receptor agonist". Neuropharmacology 60 (4): 602–608. doi:10.1016/j.neuropharm.2010.12.006. PMID 21185318.  edit
  2. ^ Riccioni, T.; Bordi, F.; Minetti, P.; Spadoni, G.; Yun, H. M.; Im, B. H.; Tarzia, G.; Rhim, H.; Borsini, F. (2011). "ST1936 stimulates cAMP, Ca2+, ERK1/2 and Fyn kinase through a full activation of cloned human 5-HT6 receptors". European Journal of Pharmacology 661 (1–3): 8–14. doi:10.1016/j.ejphar.2011.04.028. PMID 21549693.  edit
  3. ^ Tassone, A.; Madeo, G.; Schirinzi, T.; Vita, D.; Puglisi, F.; Ponterio, G.; Borsini, F.; Pisani, A.; Bonsi, P. (2011). "Activation of 5-HT6 receptors inhibits corticostriatal glutamatergic transmission". Neuropharmacology 61 (4): 632–637. doi:10.1016/j.neuropharm.2011.05.004. PMID 21619890.  edit
  4. ^ Scheggi, S.; Marchese, G.; Borsini, F.; Bordi, F.; De Montis, M. G. (2011). "Effects of the 5-HT6 receptor agonist ST 1936 on depression- and anhedonia-like experimental models". Behavioural Brain Research 224 (1): 35–43. doi:10.1016/j.bbr.2011.05.019. PMID 21645553.  edit