ST13

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Suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols ST13 ; AAG2; FAM10A1; FAM10A4; HIP; HOP; HSPABP; HSPABP1; P48; PRO0786; SNC6
External IDs OMIM606796 MGI1917606 HomoloGene2921 GeneCards: ST13 Gene
Orthologs
Species Human Mouse
Entrez 6767 70356
Ensembl ENSG00000100380 ENSMUSG00000022403
UniProt P50502 Q99L47
RefSeq (mRNA) NM_003932 NM_133726
RefSeq (protein) NP_003923 NP_598487
Location (UCSC) Chr 22:
41.22 – 41.25 Mb
Chr 15:
81.36 – 81.4 Mb
PubMed search [1] [2]

Hsc70-interacting protein also known as suppression of tumorigenicity 13 (ST13) is a protein that in humans is encoded by the ST13 gene.[1][2][3]

Function[edit]

The protein encoded by this gene is an adaptor protein that mediates the association of the heat shock proteins HSP70 and HSP90. This protein has been shown to be involved in the assembly process of glucocorticoid receptor, which requires the assistance of multiple molecular chaperones. The expression of this gene is reported to be downregulated in colorectal carcinoma tissue suggesting that is a candidate tumor suppressor gene.[3]

References[edit]

  1. ^ Zhang Y, Cai X, Schlegelberger B, Zheng S (Mar 1999). "Assignment1 of human putative tumor suppressor genes ST13 (alias SNC6) and ST14 (alias SNC19) to human chromosome bands 22q13 and 11q24→q25 by in situ hybridization". Cytogenet Cell Genet 83 (1–2): 56–7. doi:10.1159/000015125. PMID 9925927. 
  2. ^ Prapapanich V, Chen S, Nair SC, Rimerman RA, Smith DF (Oct 1996). "Molecular cloning of human p48, a transient component of progesterone receptor complexes and an Hsp70-binding protein". Mol Endocrinol 10 (4): 420–31. doi:10.1210/me.10.4.420. PMID 8721986. 
  3. ^ a b "Entrez Gene: ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)". 

Further reading[edit]