ST5 (gene)
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| Suppression of tumorigenicity 5 | |||||||||||
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| Identifiers | |||||||||||
| Symbols | ST5; DENND2B; HTS1; p126 | ||||||||||
| External IDs | OMIM: 140750 MGI: 108517 HomoloGene: 3951 GeneCards: ST5 Gene | ||||||||||
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| RNA expression pattern | |||||||||||
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| More reference expression data | |||||||||||
| Orthologs | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | 6764 | 76954 | |||||||||
| Ensembl | ENSG00000166444 | ENSMUSG00000031024 | |||||||||
| UniProt | P78524 | Q924W7 | |||||||||
| RefSeq (mRNA) | NM_005418.3 | NM_001001326.1 | |||||||||
| RefSeq (protein) | NP_005409.3 | NP_001001326.1 | |||||||||
| Location (UCSC) | Chr 11: 8.71 – 8.93 Mb |
Chr 7: 116.67 – 116.76 Mb |
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| PubMed search | [1] | [2] | |||||||||
Suppression of tumorigenicity 5 is a protein that in humans is encoded by the ST5 gene.[1][2] ST5 orthologs [3] have been identified in nearly all mammals for which complete genome data are available.
This gene was identified by its ability to suppress the tumorigenicity of Hela cells in nude mice. The protein encoded by this gene contains a C-terminal region that shares similarity with the Rab 3 family of small GTP binding proteins. This protein preferentially binds to the SH3 domain of c-Abl kinase, and acts as a regulator of MAPK1/ERK2 kinase, which may contribute to its ability to reduce the tumorigenic phenotype in cells. Three alternatively spliced transcript variants of this gene encoding distinct isoforms are identified.[2]
[edit] References
- ^ Lichy JH, Modi WS, Seuanez HN, Howley PM (Nov 1992). "Identification of a human chromosome 11 gene which is differentially regulated in tumorigenic and nontumorigenic somatic cell hybrids of HeLa cells". Cell Growth Differ 3 (8): 541–8. PMID 1390339.
- ^ a b "Entrez Gene: ST5 suppression of tumorigenicity 5". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6764.
- ^ "OrthoMaM phylogenetic marker: ST5 coding sequence". http://www.orthomam.univ-montp2.fr/orthomam/data/cds/detailMarkers/ENSG00000166444_ST5.xml.
[edit] Further reading
- Lichy JH, Majidi M, Elbaum J, Tsai MM (1997). "Differential expression of the human ST5 gene in HeLa-fibroblast hybrid cell lines mediated by YY1: evidence that YY1 plays a part in tumor suppression". Nucleic Acids Res. 24 (23): 4700–8. doi:10.1093/nar/24.23.4700. PMC 146314. PMID 8972856. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=146314.
- Majidi M, Hubbs AE, Lichy JH (1998). "Activation of extracellular signal-regulated kinase 2 by a novel Abl-binding protein, ST5". J. Biol. Chem. 273 (26): 16608–14. doi:10.1074/jbc.273.26.16608. PMID 9632734.
- Hubbs AE, Majidi M, Lichy JH (1999). "Expression of an isoform of the novel signal transduction protein ST5 is linked to cell morphology". Oncogene 18 (15): 2519–25. doi:10.1038/sj.onc.1202554. PMID 10229203.
- Majidi M, Gutkind JS, Lichy JH (2000). "Deletion of the COOH terminus converts the ST5 p70 protein from an inhibitor of RAS signaling to an activator with transforming activity in NIH-3T3 cells". J. Biol. Chem. 275 (9): 6560–5. doi:10.1074/jbc.275.9.6560. PMID 10692462.
- Amid C, Bahr A, Mujica A et al (2001). "Comparative genomic sequencing reveals a strikingly similar architecture of a conserved syntenic region on human chromosome 11p15.3 (including gene ST5) and mouse chromosome 7". Cytogenet. Cell Genet. 93 (3–4): 284–90. doi:10.1159/000056999. PMID 11528127.
- Strausberg RL, Feingold EA, Grouse LH et al (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Colland F, Jacq X, Trouplin V et al (2004). "Functional Proteomics Mapping of a Human Signaling Pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=442148.
- Gerhard DS, Wagner L, Feingold EA et al (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
- Benzinger A, Muster N, Koch HB et al (2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Mol. Cell Proteomics 4 (6): 785–95. doi:10.1074/mcp.M500021-MCP200. PMID 15778465.
- Olsen JV, Blagoev B, Gnad F et al (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
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