ST7

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See also ST6/ST7 microcontroller

Suppression of tumorigenicity 7
Identifiers
Symbols ST7 ; ETS7q; FAM4A; FAM4A1; HELG; RAY1; SEN4; TSG7
External IDs OMIM600833 MGI1927450 HomoloGene10185 GeneCards: ST7 Gene
Orthologs
Species Human Mouse
Entrez 7982 64213
Ensembl ENSG00000004866 ENSMUSG00000029534
UniProt Q9NRC1 Q99M96
RefSeq (mRNA) NM_018412 NM_001083315
RefSeq (protein) NP_060882 NP_001076784
Location (UCSC) Chr 7:
116.59 – 116.87 Mb
Chr 6:
17.69 – 17.94 Mb
PubMed search [1] [2]

Suppressor of tumorigenicity protein 7 is a protein that in humans is encoded by the ST7 gene.[1][2][3] ST7 orthologs [4] have been identified in all mammals for which complete genome data are available.

The gene for this product maps to a region on human chromosome 7 identified as an autism-susceptibility locus. Mutation screening of the entire coding region in autistic individuals failed to identify phenotype-specific variants, suggesting that coding mutations for this gene are unlikely to be involved in the etiology of autism. The function of this gene product has not been determined. Transcript variants encoding different isoforms of this protein have been described.[3]

Interactions[edit]

ST7 has been shown to interact with ITGB1BP3[5] and GNB2L1.[5]

References[edit]

  1. ^ Ogata T, Ayusawa D, Namba M, Takahashi E, Oshimura M, Oishi M (Oct 1993). "Chromosome 7 suppresses indefinite division of nontumorigenic immortalized human fibroblast cell lines KMST-6 and SUSM-1". Mol Cell Biol 13 (10): 6036–43. PMC 364663. PMID 8105370. 
  2. ^ Zenklusen JC, Rodriguez LV, LaCava M, Wang Z, Goldstein LS, Conti CJ (Feb 1997). "Novel susceptibility locus for mouse hepatomas: evidence for a conserved tumor suppressor gene". Genome Res 6 (11): 1070–6. doi:10.1101/gr.6.11.1070. PMID 8938430. 
  3. ^ a b "Entrez Gene: ST7 suppression of tumorigenicity 7". 
  4. ^ "OrthoMaM phylogenetic marker: ST7 coding sequence". 
  5. ^ a b Battle, Michele A; Maher Veronica M, McCormick J Justin (Jun 2003). "ST7 is a novel low-density lipoprotein receptor-related protein (LRP) with a cytoplasmic tail that interacts with proteins related to signal transduction pathways". Biochemistry (United States) 42 (24): 7270–82. doi:10.1021/bi034081y. ISSN 0006-2960. PMID 12809483. 

Further reading[edit]