ST8SIA1

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ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
Identifiers
Symbols ST8SIA1 ; GD3S; SIAT8; SIAT8-A; SIAT8A; ST8SiaI
External IDs OMIM601123 MGI106011 HomoloGene2282 GeneCards: ST8SIA1 Gene
EC number 2.4.99.8
RNA expression pattern
PBB GE ST8SIA1 210073 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 6489 20449
Ensembl ENSG00000111728 ENSMUSG00000030283
UniProt Q92185 Q64687
RefSeq (mRNA) NM_003034 NM_011374
RefSeq (protein) NP_003025 NP_035504
Location (UCSC) Chr 12:
22.22 – 22.59 Mb
Chr 6:
142.82 – 142.96 Mb
PubMed search [1] [2]

Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase is an enzyme that in humans is encoded by the ST8SIA1 gene.[1][2]

Gangliosides are membrane-bound glycosphingolipids containing sialic acid. Ganglioside GD3 is known to be important for cell adhesion and growth of cultured malignant cells. The protein encoded by ST8SIA1 is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to GM3 to produce gangliosides GD3 and GT3. The encoded protein may be found in the Golgi apparatus and is a member of glycosyltransferase family 29.[2]

In melanocytic cells, ST8SIA1 gene expression may be regulated by MITF.[3]

References[edit]

  1. ^ Sasaki K, Watanabe E, Kawashima K, Sekine S, Dohi T, Oshima M, Hanai N, Nishi T, Hasegawa M (Dec 1993). "Expression cloning of a novel Gal beta (1-3/1-4) GlcNAc alpha 2,3-sialyltransferase using lectin resistance selection". J Biol Chem 268 (30): 22782–7. PMID 7901202. 
  2. ^ a b "Entrez Gene: ST8SIA1 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1". 
  3. ^ Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971. 

Further reading[edit]